ID   A0A1R3H963_COCAP        Unreviewed;       667 AA.
AC   A0A1R3H963;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   ORFNames=CCACVL1_20979 {ECO:0000313|EMBL:OMO66813.1};
OS   Corchorus capsularis (Jute).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Grewioideae; Apeibeae; Corchorus.
OX   NCBI_TaxID=210143 {ECO:0000313|EMBL:OMO66813.1, ECO:0000313|Proteomes:UP000188268};
RN   [1] {ECO:0000313|EMBL:OMO66813.1, ECO:0000313|Proteomes:UP000188268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. CVL-1 {ECO:0000313|Proteomes:UP000188268};
RC   TISSUE=Whole seedling {ECO:0000313|EMBL:OMO66813.1};
RA   Alam M., Haque M.S., Islam M.S., Emdad E.M., Islam M.M., Ahmed B.,
RA   Halim A., Hossen Q.M.M., Hossain M.Z., Ahmed R., Khan M.M., Islam R.,
RA   Rashid M.M., Khan S.A., Rahman M.S., Alam M.;
RT   "Corchorus capsularis genome sequencing.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMO66813.1}.
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DR   EMBL; AWWV01012494; OMO66813.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R3H963; -.
DR   STRING; 210143.A0A1R3H963; -.
DR   EnsemblPlants; OMO66813; OMO66813; CCACVL1_20979.
DR   Gramene; OMO66813; OMO66813; CCACVL1_20979.
DR   OMA; ECVYPGV; -.
DR   OrthoDB; 1330770at2759; -.
DR   Proteomes; UP000188268; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000188268};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..667
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012503629"
FT   TRANSMEM        637..660
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..202
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   667 AA;  72378 MW;  4DD670E58CAD769D CRC64;
     MAMKFLFVAV LFYFQFHLSL SGEMNSMESV PDLQKSMYMV VDGYPCVRLI NISGEIGCSN
     PGRDKVVAPI VEYKNTKDLT QPSAVLLSMD DVEGFFSRIS KDSVFASNVG GVLVKSEDGI
     VNKLKGFSPA QKFPQAQFAP YANTTYEWNP IGSGIMWKSY NFPVFLLSES STSTLQEIAT
     KTDKTDKAYI TNVAEFDLVM QTTKVGTHDS ESCLREETCL PLGGYSVWSA LPPINSSSSN
     QSKPIILTVA SMDAASFFRD KSLGAESPIS GVISLLAAVD ALSHMDGLED LTKQLVFLVF
     TGEAWGYLGS RRFLLELDQQ SDAVHGLDST LIELVMEIGS TGWGLSQGNK TFFAHTEVVS
     SGANEVLDAL KLAQESLKSE GVTIATASSS NPGIPPSSLM AFLRKNSSTS GIVLEDFDTI
     FSNKFYQSHL DDTSNINSSS IVAAASLVAR TLYVLASNSK DLTSSSLESI NVNATLVEEL
     ISCMLDCNPG LSCELVKSYI SSKDTCPSHY VGVVLGEPSS TPYPDQVDDI SRFLWNFLAD
     RTSIPKGNTS VCSQDCGKKG GVCIRAETDQ KGVCVISTTR YVPAYSTRLK FDSGTWTLLP
     PNSSDPMGML DPVWTESNWN TIGLRVYTVQ DAAYDRLVLL SGITVTAFAY LAIVLTRAYV
     IKALKQD
//