ID A0A1R3RB40_ASPC5 Unreviewed; 1244 AA.
AC A0A1R3RB40;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPCADRAFT_211036 {ECO:0000313|EMBL:OOF91682.1};
OS Aspergillus carbonarius (strain ITEM 5010).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=602072 {ECO:0000313|EMBL:OOF91682.1, ECO:0000313|Proteomes:UP000188318};
RN [1] {ECO:0000313|Proteomes:UP000188318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ITEM 5010 {ECO:0000313|Proteomes:UP000188318};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV907510; OOF91682.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R3RB40; -.
DR STRING; 602072.A0A1R3RB40; -.
DR VEuPathDB; FungiDB:ASPCADRAFT_211036; -.
DR OMA; DWPGPDS; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000188318; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000188318};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 85..145
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 815..948
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 984..1220
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 30..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 139205 MW; 8E83F1EEEDD1B87B CRC64;
MFDSRAAEPL AVDTGSALAT KTNTYTAAFE YPEEQVTTPT TGQRSRGDSL SFPQPTLAAD
QSPNRRISSM KMTTDGRYTP SPEPPPALFV RAMYDYDADD HTSLSFRRGD IIQVLNQLET
GWWDGVIDNS VRGWFPSNYC TVITDLEELE EQVSQVQVHE NEEVSAESGA GEEYEEEPEG
DEVDSAGNPR DSQPILPIEG VGAPQEQEEA AFWIPQATPD GRLFYFNTLT GYSTMELPFE
NPAANETGPY DRNNFLVPDQ TRPPPEMMAR GFERDEDDYD GSASEAEGES LMLTSRDSMS
RRRQSYLDGV SPATSMDSLH PPSATKSIND GNSSHQSLLN LHKLYDSAAS SSNSLSDNVH
RPSVSSEVPS HFVDDGVSVQ LTWPLLVDNM RQAVEVYRQT LLNGDRSEYV RKAEDISDHL
RMLLAAGSDT TDNHSGNPSV ISTNKALYPH FRDMMSKFSK LVLSSHIAAA DWPGPDSINK
CLQEADGVMQ GVYGYVEVAR QQRGETIRRI VPGFVVGSFS GGCWQNNGVS LSDSGPTSFL
DHDASDSRAE PSVTLDAALL EQIDILRRSF VGSIRRLEER LTLNKKKIVT VAEHEEIGNS
VSAAAIKVIE QFRPWISAVE SINLAPLGTS FQNPQLVDFS LQKQRTYDAI ADFVLSCQAV
SAPLGDEWAE LRGDSLDDRL NAVRGVHRQL ENYVSQIGFS LSLLLEQVPE PTAVFRAESR
LGGENPGPKG IHSRSESQVG VATESIGIPS SYSVEGTSEK VRRNMDKAQR FFGQAPPAAI
PREPPIREPV REPEETPWFL KTDHEGEVFY DTKNDNPALK CGTLAGLVEQ LTRHDKLDAS
FNNTFLLTYR SFTSASELFE MLTQRFNIQP PFGLNPDEMQ MWVDRKQKPI RFRVVNILKS
WFENFWMEPN DEPHMALLQH VHAFTKDSIA TTKTPGSPQL LAVIEQRLRG QDNTVKRLVP
TQATAAPTPI IPKNMKKLKF LDIDPTEFAR QLTIIESRLY SKIRPTECLN KTWQKKVGPD
EPEPATNVKA LILHSNQLTN WVAEMILNQS DVKKRVVVIK HFVNVADKCR ALNNYSTLTS
IISALGTAPI HRLGRTWAQV SGRTSTVLEQ MRRLMASTKN FGEYRETLHL ANPPCIPFFG
VYLTDLTFIE DGIPSLTPSE LINFNKRAKT AEVIRDIQQY QNVPYLLQPV PELQDYILSN
LQNAGDVHDM YDRSLEVEPR EREDEKIARR GHLSRNIELW KTSE
//