ID A0A1R3RTG5_ASPC5 Unreviewed; 1110 AA.
AC A0A1R3RTG5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPCADRAFT_205014 {ECO:0000313|EMBL:OOF97757.1};
OS Aspergillus carbonarius (strain ITEM 5010).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=602072 {ECO:0000313|EMBL:OOF97757.1, ECO:0000313|Proteomes:UP000188318};
RN [1] {ECO:0000313|Proteomes:UP000188318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ITEM 5010 {ECO:0000313|Proteomes:UP000188318};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV907496; OOF97757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R3RTG5; -.
DR STRING; 602072.A0A1R3RTG5; -.
DR VEuPathDB; FungiDB:ASPCADRAFT_205014; -.
DR OMA; EEVWERD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000188318; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000188318};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..76
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 644..764
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 824..1067
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 216..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 122824 MW; 10EA7203DC97A228 CRC64;
MEHTEMPRAV FHNYLRAFYP YHPSGNVSPS TVTLPLDQGD IVLVHSVHTN GWADGTLLDT
GARGWLPTNY CEAYDQQPMR PLLKALTDFW DIIRGGCGFP LNDAGNQDLV RGLIAGVRYL
LQKSECLTRD CILVTSHDGL RRNRKALLAD LSSLVRTTKR FQEVGSSSAT QDEIDYMVDE
MLLKAFRIVT RGVRFLDVWN EEVGLSRTIA ELEQQSAHHQ GPLASAAETG PISEAAASEA
DTERNESRLM NRSRLDMSRA STRADDAQQT RPMSVTTKRI SISHRVSTSG PAAAARNPNL
ASERLNAAYD AFLGVLGSFI GLHLQSRSST ELVVTTEQAV RSCRALLTVV EATCEHDPQG
SGLLEGARDT MYERLSELVY AARDAFRPAH SPDDELVFLP DEGKRLVDAA TDCVRAAGSC
LAKARLMLEE CGDFELDAMP QDLAPAAPAV TDVNKTPQPQ RTSSLPVNQG RPQEGSLRLP
PPPLQIPTSI NNRYSPPTPG LTDDTTPSSF QSRGGASTPA TDMSSFPSTN LLSSSLDKLS
FSSNDTQPIE IPHRNSQPKS DVSESFGRGV TSNGSSFTFT SRLRDSEMSG VSQTSTRATS
PDIGNHYQVP SLKGSISHST LAEENEETEA NILEKTYAHE LIFKDGQVMG GSLRALVEKL
TAHQSTPDAM FVSTFYLTFR LFATPVEFAE TLVDRFNYIG DTPHTAGPVR LRVYNVFKGW
LESHWRHDCD NSALGYIVEF ANTTLMGTLP SAGKRLAELA DKVSMVHGPV VPRLVSSMGK
TNTATAQYVH PDTPLPPPIL GKKEANLLKQ WKNGEGTISI LDFDPMELAR QFTIKESRIF
CAILPEELLA TEWMKKSGSL AVNVRAMATL STDLTHLVAD SILQLEEPKK RAAIIKHWVK
IANKCLELSN YDSLMAIICS LNSSMISRLK RTWEVVSQKT KTTLEYLRGI VDVSRNYFVL
RQRLQNRVPP CLPFVGTYLT DLTFVDHGNQ ALRNLPTDEG EMAVINFDKH MKTAKIISEL
QRFQIPYRLT EVPELQAWMQ NELVRVRSSG EKSLQTFYRR SLVLEPREAS QPRNMQPESS
SSSILENAKD KFDFLSWTHP SKAKSVATNG
//
