ID A0A1R3TA05_9BACT Unreviewed; 353 AA.
AC A0A1R3TA05;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|HAMAP-Rule:MF_00955};
GN Name=gmd3 {ECO:0000313|EMBL:SCD21447.1};
GN Synonyms=gmd {ECO:0000256|HAMAP-Rule:MF_00955};
GN ORFNames=PSM36_2651 {ECO:0000313|EMBL:SCD21447.1};
OS Proteiniphilum saccharofermentans.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Proteiniphilum.
OX NCBI_TaxID=1642647 {ECO:0000313|EMBL:SCD21447.1, ECO:0000313|Proteomes:UP000187464};
RN [1] {ECO:0000313|EMBL:SCD21447.1, ECO:0000313|Proteomes:UP000187464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3/6 {ECO:0000313|EMBL:SCD21447.1};
RA Seilhamer J.J.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-
CC deoxy-D-mannose. {ECO:0000256|HAMAP-Rule:MF_00955}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O;
CC Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:57964; EC=4.2.1.47; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00955};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937,
CC ECO:0000256|HAMAP-Rule:MF_00955};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263, ECO:0000256|HAMAP-Rule:MF_00955}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00955}.
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DR EMBL; LT605205; SCD21447.1; -; Genomic_DNA.
DR RefSeq; WP_076931295.1; NZ_LT605205.1.
DR AlphaFoldDB; A0A1R3TA05; -.
DR STRING; 1642647.PSM36_2651; -.
DR KEGG; psac:PSM36_2651; -.
DR Proteomes; UP000187464; Chromosome i.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070401; F:NADP+ binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01472; gmd; 1.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|HAMAP-Rule:MF_00955, ECO:0000313|EMBL:SCD21447.1};
KW NADP {ECO:0000256|HAMAP-Rule:MF_00955};
KW Reference proteome {ECO:0000313|Proteomes:UP000187464}.
FT DOMAIN 5..340
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 353 AA; 40465 MW; F1E8A899C725AA09 CRC64;
MKKALITGIT GQDGSYLAEL LLEKGYEVHG TLRRSSSFNT GRIEHLYLDE WIRDMKQRRL
INLHYADMTD SSSLIRIIQH IQPDEIYNLA AQSHVKVSFD VPEYTAETDA VGTLRLLEAV
RILGLEKTTR IYQASTSELY GLVQEIPQKE TTPFYPRSPY GVAKLYGYWI TKNYRESYGM
FAVNGILFNH ESERRGETFV TRKISLAAAR IAQNLQDKLY MGNLDAKRDW GYAPDYVECM
WLMLQHEVPE DFVIATGEMH SVREFCTLAF AEAGIALRWE GEGAAEKGID MATGRILVEV
DPRYYRPAEV EKLLGDPTKA KTLLGWNPRK TSFEELVRRM VKNDMETVRK LSP
//
