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Database: UniProt
Entry: A0A1R3TKY2_9RHIZ
LinkDB: A0A1R3TKY2_9RHIZ
Original site: A0A1R3TKY2_9RHIZ 
ID   A0A1R3TKY2_9RHIZ        Unreviewed;       425 AA.
AC   A0A1R3TKY2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 9.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:SCX17509.1};
GN   ORFNames=DSM25559_1599 {ECO:0000313|EMBL:SCX17509.1};
OS   Agrobacterium sp. DSM 25559.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=1907666 {ECO:0000313|EMBL:SCX17509.1, ECO:0000313|Proteomes:UP000187891};
RN   [1] {ECO:0000313|EMBL:SCX17509.1, ECO:0000313|Proteomes:UP000187891}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM25559 {ECO:0000313|EMBL:SCX17509.1};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; FMUE01000003; SCX17509.1; -; Genomic_DNA.
DR   RefSeq; WP_077119335.1; NZ_FMUE01000003.1.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000187891; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000187891};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:SCX17509.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187891}.
FT   DOMAIN      107    312       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   REGION      215    234       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1R3TKY2}.
SQ   SEQUENCE   425 AA;  44885 MW;  0D4D5C59BD4351EA CRC64;
     MKVLLIGSGG REHALAWKIA QSPRLTQLFA APGNPGIAEH ATLVTLDVED HAAVIAFTKE
     NDIDFVIVGP EAPLVAGLAD DLRAVGIATF GPSKAAAQLE GSKGFTKDLC ARYDIPTGAY
     KRFKAAEPAK EYVRQQGAPI VIKADGLAAG KGVTVAMTEA EAVSAIDDCF DGAFGSAGAE
     VVVEAFLDGE EASFFCLSDG KTALALATAQ DHKRVGDGDT GPNTGGMGAY SPAPVMTPEM
     VERTMKEIIE PTISGMAKDG NPFSGVFFAG LMITQKGPEL IEYNVRFGDP ECQVLMMRLK
     SDLLPILYAT ATGTLDQVTA DWRDDAALTV VLASKGYPAS YDKNTPIDHI PEAREDAKVF
     HAGTALKDGQ LVATGGRVLN VTAFGTTVTE AQSRAYALAK EVKWDNGFSR SDIGWQAVAR
     EKQSH
//
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