ID A0A1R3UEC2_9ACTN Unreviewed; 976 AA.
AC A0A1R3UEC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Na(+) H(+) antiporter subunit A Na(+) H(+) antiporter subunit B {ECO:0000313|EMBL:SIO84166.1};
GN ORFNames=BQ8420_00520 {ECO:0000313|EMBL:SIO84166.1};
OS Nocardiopsis sp. JB363.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1434837 {ECO:0000313|EMBL:SIO84166.1, ECO:0000313|Proteomes:UP000195722};
RN [1] {ECO:0000313|EMBL:SIO84166.1, ECO:0000313|Proteomes:UP000195722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB363 {ECO:0000313|EMBL:SIO84166.1,
RC ECO:0000313|Proteomes:UP000195722};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; FRFF01000002; SIO84166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R3UEC2; -.
DR Proteomes; UP000195722; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..91
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 108..394
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 587..651
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 662..750
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 816..938
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 976 AA; 103982 MW; 819D5F51AA8CBF2C CRC64;
MIRQWGRNGF YALAIVPGLA TIWTLFQLPT ILNGGTLSES MEWAPQFSLR LGVHMDALGL
VMTLIAGGVG TLILAYCARY FSDSDEGLPR FAGVFVAFAG AMLGLVLADD LIQLFIYWEL
TTVFSYLLVG HKAESKDSRR AAMTALVVTT FGGLAMLVGM IMLGETAGTY IISEIVANPP
AGGAVVNSAL ALIMLGAMSK SALFPFSLWL PAAMQAPTPV SGYLHAAAMV KAGVYLVARL
TPAFGDVTVW TTMALFFGVI TMIFGGWKAL RQFDLKLVLA YGTISQLGFL IALLGTGTRA
AALAGIAMLV AHALFKAPLF LIVGIIDHST GTRDLRELSG LRKSMPSTFW ITVVALASMS
GLPPTAGFVA KELAFGAYTE SGGLDTLVLV GLVIGSTLTV AYSLRFLWGA FLDKEGVQPN
EVHAPGPLFL APAVILAALS LIGGLFSGGV DRLFATYADT VPLGPSEEYP TYLALWHGWE
LPLLLSAVCV VGGLVLFYFR HRVAWLGNRL AYVNPERNYR RMMAGLETLA LQVTGSTQRG
SLPVYLGTIL VFLVITAGIP MITGRLWEGD YPTLRLWDTP VQVIPAVIIV ITCLMILFVR
RRLFAVILVG IGGYGVGALF YFQGAPDIAL TQFLVETVSL VVFVLVLRRF PSHFSAPALK
GRRIWNMVIG AATGLLVATM TWFALAGRQE PSIAVGGPDD PSYVDAAEKA GGDNLISVLL
VDVRAWDTMG EISVLAAAAA GVASLMFVRR RAQPRKAPGG VMALSVTQSL QPANGDDRLD
LSGLKVAPKN MHVRPQWNRS WLPGAEALPT ERRSIIFEVV SRFLFPVIMV ISVYLLLTGH
TDVGGGFAGG IVAGLAFIVR YLAGGRFELY ATAWVQPGAL IGAGLALATG TALAGAFFLG
DVLAGADFYL GFGFLGEAHV TVSMLFDIGV YLLVIGLILD ILRSLGARID EQIERDAAHS
EAVDPGTTSP AEEVTS
//
