ID   A0A1R3UGS2_9ACTN        Unreviewed;       378 AA.
AC   A0A1R3UGS2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Threonine dehydrogenase and related Zn-dependent dehydrogenases {ECO:0000313|EMBL:SIO85069.1};
GN   ORFNames=BQ8420_05100 {ECO:0000313|EMBL:SIO85069.1};
OS   Nocardiopsis sp. JB363.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Nocardiopsis.
OX   NCBI_TaxID=1434837 {ECO:0000313|EMBL:SIO85069.1, ECO:0000313|Proteomes:UP000195722};
RN   [1] {ECO:0000313|EMBL:SIO85069.1, ECO:0000313|Proteomes:UP000195722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB363 {ECO:0000313|EMBL:SIO85069.1,
RC   ECO:0000313|Proteomes:UP000195722};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; FRFF01000025; SIO85069.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R3UGS2; -.
DR   Proteomes; UP000195722; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd08282; PFDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000195722}.
FT   DOMAIN          4..373
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   378 AA;  41263 MW;  4B4514CA7F3AE9AD CRC64;
     MYNGSRDVSV KEVPDARIER PTDVLVRITA TNICGSDLHM YEGRTDLEPG KVLGHENLGV
     VIEIGDGVER VKVGDHVCLP FNIGCGFCRN CESGMPSYCL TANPDPEMAG AAYGFAGMGP
     FSGGQAEYLR VPFGDFNCLR LPEDAQEKED DYVMVADIFP TGWHATRLAG LKPGESCVVY
     GAGPVGLMAA YSALLQGASQ VMVVDRHPDR LRLVERMGAI PVDDSKGDPV EQILNLTDGR
     RADCGCECVG YQAHDHLGVE HPEMTMNNLV KSVKFTGGIG VVGIFLPSDP GASDEMARNG
     RLDFEMGTFW FQGQRIGTGQ APVKAYNRQL RDMIHQDRAK PSFIVSHDLP LQRAPEAYEH
     FDNREDGWTK VVLKPAMA
//