ID   A0A1R3UME1_9ACTN        Unreviewed;       346 AA.
AC   A0A1R3UME1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=HNH nuclease domain-containing protein {ECO:0000259|SMART:SM00507};
GN   ORFNames=BQ8420_08445 {ECO:0000313|EMBL:SIO85732.1};
OS   Nocardiopsis sp. JB363.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Nocardiopsis.
OX   NCBI_TaxID=1434837 {ECO:0000313|EMBL:SIO85732.1, ECO:0000313|Proteomes:UP000195722};
RN   [1] {ECO:0000313|EMBL:SIO85732.1, ECO:0000313|Proteomes:UP000195722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB363 {ECO:0000313|EMBL:SIO85732.1,
RC   ECO:0000313|Proteomes:UP000195722};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
CC       {ECO:0000256|ARBA:ARBA00023450}.
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DR   EMBL; FRFF01000051; SIO85732.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R3UME1; -.
DR   Proteomes; UP000195722; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 1.10.30.50; -; 1.
DR   InterPro; IPR003870; DUF222.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   Pfam; PF02720; DUF222; 1.
DR   Pfam; PF01844; HNH; 1.
DR   SMART; SM00507; HNHc; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000195722}.
FT   DOMAIN          252..303
FT                   /note="HNH nuclease"
FT                   /evidence="ECO:0000259|SMART:SM00507"
FT   REGION          321..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  38484 MW;  40CB71F807F18C40 CRC64;
     MHRQQLPLVD EAFGDSTLSL GEACAIATST EKATAEWAKV LDSADEAFKA DHPDVEGFRA
     RLEFGLIAYK KECPKASVRQ LRDAAKWFVA QLDPDKADRD YDETFDNRGA QFSPTFEGGF
     LLRMWGPGAD NQLIQAALDA YTEPYGPDSA AIPKHQRTYD AMMRIFETAL GHRKCAKAPK
     PVVTLNITVP LKRYLGDASA EPAVTEDGVV IPDQMISRLT PKSWLRRFLT DAEGKTLLDV
     GQKHRCAPDP VRQAAGYKEF HCEWHEGCDM PRSWSQFDHI IAFSHGGATS SDNMQLLCST
     HNRLKHRLQV KANQQIWDHH HTQNRQETEK DGGGEGGEGD PAPATA
//