ID   A0A1R3UTW4_9ACTN        Unreviewed;      2094 AA.
AC   A0A1R3UTW4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:SIO90366.1};
GN   ORFNames=BQ8420_26290 {ECO:0000313|EMBL:SIO90366.1};
OS   Nocardiopsis sp. JB363.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Nocardiopsis.
OX   NCBI_TaxID=1434837 {ECO:0000313|EMBL:SIO90366.1, ECO:0000313|Proteomes:UP000195722};
RN   [1] {ECO:0000313|EMBL:SIO90366.1, ECO:0000313|Proteomes:UP000195722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB363 {ECO:0000313|EMBL:SIO90366.1,
RC   ECO:0000313|Proteomes:UP000195722};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FRFF01000168; SIO90366.1; -; Genomic_DNA.
DR   OrthoDB; 3802848at2; -.
DR   Proteomes; UP000195722; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195722}.
FT   DOMAIN          957..1031
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2014..2089
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2094 AA;  225899 MW;  BD9D934A3DA1417C CRC64;
     MSRSLSMVEE AIWIESNSER GSLSYNIPYV VELEGDIDHA ALATAFGDLV RAHPALRTGY
     RRRRGEVVAE LLDEVAPRVE FVDLRDTLEH DAELRRMIAV AVGTTMDLSD PPLMRILHVR
     TRGDSGGVLC VVLHHLIGDG RSREILFADL AEFISDRTMG REPRHREHGE YDYARWSRDG
     RARERRDDAN REFWSRRLAA ADPGALGRFL GQGRVETRRH IREARITGGD LAGIRRSAAR
     NRWTLNTVLT SALSVAIGRL AAVRDVCLGV VTGNRGPEVA DVVGAFAATV PALIRVRPET
     TFEEHTRAVS RETREIAVRP AIPLHVLAGS GPVPDTWRSA FDMRLVHTFR PERLRLGDVP
     VRPMEGEPPR GRSMVTVNVQ ESRGELVLSV DHDPDTVDSE AVGALLELML RVLEEGLESP
     RTPLPSMART IAEPHSDPDF SVPRVTGGVG GLVSVFDRSV AVGPGRVAVR DGGGEVSYGR
     LAELSRAVAA GLAERGVCVG ERVGVCVGRD ARLPAVILGV LRVGAVYVPL DPEHPRSRLG
     YCARDAGVGV VVTDDSTFDL FEPSDSSDSS GGVRVEPVLV DDLLACTGPV PVVDVVGESP
     AYVMYTSGST GRPKGVTVCH GNVMWLVDAA LPLVEASSRD VWSFFHSYAF DVSVWEMWGA
     LASGGTLVMV PRDVAREPER LVELLAGSGV SVLSQTPTAF TQVSAHLGRL PDLRMVVFGG
     ERLSPSVVSD VDPRVRLVNM YGITETTVHV TFHEVDQKMK GSPVGRGMPG ADVYVLDSFL
     QPVPVGVVGE IFVSGGGVVQ GYHGRSGLTA GRFVPDPFSG SGRRMYRSGD LARVLSDGSL
     DYVGRSDAQV KVNGYRVEPA EIEFVVSGCP GVGECAVVVV SVGGADRVVA YVVPVPGVEL
     DSVVVREFVG SRLPSHMVPA YFVEMGGLPL TVNGKLDRSS LPVPGADRVG MRNSFVAPRS
     EMERLVCGVW ESVLGVSPVG IDDNYFELGG DSIRAVQIIG ALEEKGWRAD LDDFYNAPTV
     AELTELVHAT QERDTPTPFE LIDDDERSRL PEGAVDAYPM TATQVGMHLQ AELNGEGRVY
     HNVNSVELRA LLDEDAFVSA VAAAVRRHPV LRTGFQVEGS RRFLQVVHAR ALACVRVHDL
     RDRTREEQET WIAGVVEEEL AEPFDMVTPP LLRFRLLRRS DDAFQLVVAE NHVILDGWSF
     TSLLVEIWED HLALTGDATE PDEPRELRTS FAEFVRLESE AVESEAARAY WTEEFADAVP
     TRYAEISGTE ELPQRVARRT VPIDEELERS LRKLAADLGV PIKSVLLAAH VRVLSALVGR
     ADVVTGLVTN GRPERPDGDA VKGLFLNTVP VRGRVGSGTW SDLVGELYET ERRMLPHRRF
     PLGAINRELG VRDLFDCAFH FVEFHETKRL LSDRLLQGMA GSDLSSENTH FRLLAAFSVH
     PPENRLGLVL AYDTATFGDH IDLVAESYLK ALRGIAANPG EHCARFRIGD LPPDTMERLP
     STTGGVGGLV SVFDRSVAVG PGRVAVRDGG GEVSYGRLAE LSRAVAAGLA ERGVCVGERV
     GVCVGRDARL PAVILGVLRV GAVYVPLDPE HPRSRLGYCA RDAGVGGVVT DDSTFDLFEP
     SDSSDSSGGV RVEPVLVDDL LACTGPVPVV DVVGESPAYV MYTSGSTGRP KGVTVCHGNV
     MWLVDAALPL VEASSRDVWS FFHSYAFDVS VWEMWGALAS GGTLVMVPRD VAREPERLVE
     LLAGSGVSVL SQTPTAFTQV SAHLGRLPDL RMVVFGGERL SPSVVSDVDP RVRLVNMYGI
     TETTVHVTFH EVDQKMKGSP VGRGMPGADV YVLDSFLQPV PVGVVGEIFV SGGGVVQGYH
     GRSGLTAGRF VPDPFSGSGR RMYRSGDLAR VLSDGSLDYV GRSDAQVKVN GYRVEPAEIE
     FVVSGCPGVG ECAVVVVSVG GADRVVAYVV PVPGVELDSV VVREFVGSRL PSHMVPAYFV
     EMGGLPLTVN GKLDRSSLPV PGADRVGMRN SFVAPRSEME RLVCGVWESV LGVSPVGIDD
     NYFELGGNSI TAVEIAEELS EAVDGDVDFV AVYGSATVAG LAERIATDLE DNDV
//