ID A0A1R3W5L8_9MICO Unreviewed; 708 AA.
AC A0A1R3W5L8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SIT72002.1};
GN ORFNames=SAMN05880545_0978 {ECO:0000313|EMBL:SIT72002.1};
OS Microbacterium sp. RU33B.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1907390 {ECO:0000313|EMBL:SIT72002.1, ECO:0000313|Proteomes:UP000187047};
RN [1] {ECO:0000313|EMBL:SIT72002.1, ECO:0000313|Proteomes:UP000187047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU33B {ECO:0000313|EMBL:SIT72002.1,
RC ECO:0000313|Proteomes:UP000187047};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; FTPO01000001; SIT72002.1; -; Genomic_DNA.
DR RefSeq; WP_076680345.1; NZ_FTPO01000001.1.
DR AlphaFoldDB; A0A1R3W5L8; -.
DR STRING; 1907390.SAMN05880545_0978; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000187047; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187047};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 164..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 537..666
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 708 AA; 73568 MW; 91F4E8DA88D8D1AE CRC64;
MGGLTRFITS AKTSWIMLVL AALAAVALFS IAGGEESETA PSVGLPDSAE SVQVDELLEE
FPGEEGTSAL LVFAAEDGEL NAETLAAIDA KVFGDLTSFA REDFVPPAQV SEDGTVALVV
VPLETESDVE AQAERAQEIR DVASADLDGV RVYLTGAEGF EVDIAAVFAG ADFTLLLTTV
IVVAVLLLIT YRSPWLWLVP LVVIGLADAL AGIVARQVAA AVGVQLDASV TGILSVLVFG
AGTNYALLLI ARYRDELRLH ESRRTAMQRA LRGAGPAIIA SGSTVALALL TLLLAELGGN
RALGLACAVG IVVAMIFALF VLPAALVLFG RGLFWPYIPR FGSADAISRS VWGKLGRGVA
KRPIVVATVG FVVLGAMASG LLFLQTGLSQ NDRFIQKPEA VQGQEVLAEA FSAGTTSPAV
VVVPLDDAED AALALADLEG VDSAVVGDTT DDFAQISVTL NANAESQEAF ATVERMRAAL
DDVGSGEGLV GGLDATALDV KNAQARDQSL LIPLILVLVF LVLVILLRAL VAPLLLLLAV
VASFFSAVGL SWWIFQSPLF GFPAIDTNVL LFSFLFLVAL GVDYSIFLVT RAKEEAEHLG
ITQGMIRALA ATGAVITSAG ILLAAVFAVL GVLPLITLTQ IGIIVCVGVL IDTLLVRTVI
VPALAFITRD AFWWPRKPTL TDAEAATQGA DALAPATTAA AATATAAS
//