ID A0A1R3WCY7_9RHOB Unreviewed; 371 AA.
AC A0A1R3WCY7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=aminomethyltransferase {ECO:0000256|ARBA:ARBA00012616};
DE EC=2.1.2.10 {ECO:0000256|ARBA:ARBA00012616};
DE AltName: Full=Glycine cleavage system T protein {ECO:0000256|ARBA:ARBA00031395};
GN ORFNames=SAMN05421849_0369 {ECO:0000313|EMBL:SIT75689.1};
OS Pontibaca methylaminivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Pontibaca.
OX NCBI_TaxID=515897 {ECO:0000313|EMBL:SIT75689.1, ECO:0000313|Proteomes:UP000192455};
RN [1] {ECO:0000313|EMBL:SIT75689.1, ECO:0000313|Proteomes:UP000192455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21219 {ECO:0000313|EMBL:SIT75689.1,
RC ECO:0000313|Proteomes:UP000192455};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-
CC aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-
CC methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-
CC lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475,
CC Rhea:RHEA-COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00043710};
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; FTPS01000001; SIT75689.1; -; Genomic_DNA.
DR RefSeq; WP_076646743.1; NZ_FTPS01000001.1.
DR AlphaFoldDB; A0A1R3WCY7; -.
DR STRING; 515897.SAMN05421849_0369; -.
DR OrthoDB; 9774591at2; -.
DR Proteomes; UP000192455; Unassembled WGS sequence.
DR GO; GO:0004047; F:aminomethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 4.10.1250.10; Aminomethyltransferase fragment; 1.
DR InterPro; IPR006223; GCS_T.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR00528; gcvT; 1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR PIRSF; PIRSF006487; GcvT; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Methyltransferase {ECO:0000313|EMBL:SIT75689.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192455};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SIT75689.1}.
FT DOMAIN 9..254
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 285..365
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 371 AA; 39356 MW; 1BEE9E0BEBEBA1CC CRC64;
MSALQQTPLH ALHEERGGKM VDFTGYSLPV QYKSGIMAEH LHTRQAASLF DVSHMGQVIL
SGEGAAAALE TQMPSDVLGL PEGRQRYGFF TSSDGGILDD LMFANRGDHL FLVVNAACKR
ADIARLKAAL EPAVKVREVT DRGLLALQGP LAELVLAAFD PDAAGMRFMD IRTLTLDGVE
AWVTRSGYTG EDGYEISLPA GATEAFARRL LEHEAVELAG LGARDSLRLE AGLCLYGNDI
DETTRPGEAG LGWAIPGVRR RGGAREGGFP GAEAVLSDLE RGPARRRVGL RPEGRAPMRG
GVPLHADENS DTAVGRITSG GFGPSVGAAI AMGYVPADLA SPGTRLYGDL RGRRLPVEVV
PLPFVAAGHK R
//
