ID A0A1R3X796_9MICO Unreviewed; 591 AA.
AC A0A1R3X796;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Monovalent cation:H+ antiporter, CPA1 family {ECO:0000313|EMBL:SIT86090.1};
GN ORFNames=SAMN05880579_1637 {ECO:0000313|EMBL:SIT86090.1};
OS Microbacterium sp. RU1D.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1907411 {ECO:0000313|EMBL:SIT86090.1, ECO:0000313|Proteomes:UP000187105};
RN [1] {ECO:0000313|EMBL:SIT86090.1, ECO:0000313|Proteomes:UP000187105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU1D {ECO:0000313|EMBL:SIT86090.1,
RC ECO:0000313|Proteomes:UP000187105};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; FTPQ01000001; SIT86090.1; -; Genomic_DNA.
DR RefSeq; WP_076674825.1; NZ_FTPQ01000001.1.
DR AlphaFoldDB; A0A1R3X796; -.
DR Proteomes; UP000187105; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 54..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 82..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 111..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..398
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 475..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 63110 MW; 6BAB263873557CD8 CRC64;
MQGLEITVLL GLAMLVGTIL APRLRVATPL VLLVIGLALG FIPELRQIEL PPETVLLLFL
PIMLFREAWT TSLRSVRRSL RYIIPMSTLL VVASAFAVAG VATLLGVPWE AALVLGAAVA
PPDATAVAAL GRLLPAKTFM KLKAESLTND GTALVLYAIA VALLLGDQIT PLQITGMVLL
SYLGGAAAGI AVAAAAFFAL RRMQSTLTIN LTMVLVPFVS FLIAELIEAS GVLAVVFAGL
IMAWVSPRIT TAMSRRAADA TWPFGVYLLN GALFVLIGLE VQLVLHEISG SEIGILLLVT
VAAWIALFVV RYLFQWMFSP FSRPAAGSSR SLRHRSRIVS TVAGFRGAVS LAIALSVPVT
TSAGDPVAGR DAIVFVTAGV IVLTLLVQGP LLPAVIKWAK LPNDDAAIEE YELAERAISG
AALAALDDLA IEHGISDRVR DRARREGYER LELANARAIA RQRAIEERDL AELDASLDDD
SSATGPVPPD GSEVDRRSGG RAVDGADAEG AAFTGPLQMI AVSEDIDVTQ RSPLLRHKEA
QRLRLAVLDR KREVLLRLRR EGTIDDLVAR KILAGLDLEE IRARGIEKAS D
//
