ID   A0A1R4ABH0_BABMR        Unreviewed;      1084 AA.
AC   A0A1R4ABH0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE            EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN   ORFNames=BMR1_03g01705 {ECO:0000313|EMBL:SJK86373.1};
OS   Babesia microti (strain RI).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=1133968 {ECO:0000313|EMBL:SJK86373.1, ECO:0000313|Proteomes:UP000002899};
RN   [1] {ECO:0000313|EMBL:SJK86373.1, ECO:0000313|Proteomes:UP000002899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RI {ECO:0000313|EMBL:SJK86373.1,
RC   ECO:0000313|Proteomes:UP000002899};
RX   PubMed=22833609; DOI=10.1093/nar/gks700;
RA   Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V.,
RA   Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B.,
RA   Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H.,
RA   Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T.,
RA   Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V.,
RA   Ben Mamoun C.;
RT   "Sequencing of the smallest Apicomplexan genome from the human pathogen
RT   Babesia microti.";
RL   Nucleic Acids Res. 40:9102-9114(2012).
RN   [2] {ECO:0000313|EMBL:SJK86373.1, ECO:0000313|Proteomes:UP000002899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RI {ECO:0000313|EMBL:SJK86373.1,
RC   ECO:0000313|Proteomes:UP000002899};
RX   PubMed=27752055; DOI=10.1038/srep35284;
RA   Silva J.C., Cornillot E., McCracken C., Usmani-Brown S., Dwivedi A.,
RA   Ifeonu O.O., Crabtree J., Gotia H.T., Virji A.Z., Reynes C., Colinge J.,
RA   Kumar V., Lawres L., Pazzi J.E., Pablo J.V., Hung C., Brancato J.,
RA   Kumari P., Orvis J., Tretina K., Chibucos M., Ott S., Sadzewicz L.,
RA   Sengamalay N., Shetty A.C., Su Q., Tallon L., Fraser C.M., Frutos R.,
RA   Molina D.M., Krause P.J., Ben Mamoun C.;
RT   "Genome-wide diversity and gene expression profiling of Babesia microti
RT   isolates identify polymorphic genes that mediate host-pathogen
RT   interactions.";
RL   Sci. Rep. 6:35284-35284(2016).
CC   -!- SIMILARITY: Belongs to the synaptojanin family.
CC       {ECO:0000256|ARBA:ARBA00008943}.
CC   -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC       trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
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DR   EMBL; LN871598; SJK86373.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4ABH0; -.
DR   VEuPathDB; PiroplasmaDB:BMR1_03g01705; -.
DR   OrthoDB; 996872at2759; -.
DR   Proteomes; UP000002899; Chromosome IIIa.
DR   GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR046985; IP5.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR002013; SAC_dom.
DR   PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR   PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR   Pfam; PF02383; Syja_N; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50275; SAC; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:SJK86373.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002899}.
FT   DOMAIN          211..711
FT                   /note="SAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50275"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1084 AA;  123405 MW;  AE887A5EB8BDDE52 CRC64;
     MYEGGNSDES SLDSLSEHGE NKSLDDRSIS FGVDTEYLYE REVKVNSMED RHRYDIYFYH
     KWILIKRPNV TTDLNLWIDR ETCECKECYG SPASPGECPI IRECAYAILG VLRISLSTYL
     VIVTQETFVT TINLPGRHKI SVYMIASAVC LAISPMGVGA VDEYIVPSPG AIKKSIGTAT
     NWISQHFKLG LDRDSTGSED YRSEIKRQIL LVERLLENGF YYSINEDLGV KFQDLYTHET
     YKFNSCTTAS SNLYNTSKCN VNHDTGSAAD TDDELFDFMK NCNKNVPENN DPYKNDNNNK
     SDTASSRLDS NAASDVKFQK KLFEKHCKCV WSSSGNDSFK WNLNMGIGFP CCWLTSVIQG
     YYASQTTLTP QGELTLILIG RRSIYKPGTR ITCRGIDDKG HVANFVETEL AVILPNGHLS
     SVVMCRGSVP IFWEQTGVMS SPNVTHCVEM LKRPFLTHFS ELCSQYGDIL CVNLLNDRWE
     LCLTEAYSNV LQCVNRRFLL NQFGGGDAIN DKSSERVNLF DLPESTSNSN TGIGIGTNNK
     FGVDVNNLES DGMNDGQKNS PVEELQCLIS YPFTGDLSEC SISLINYNFA SNVNIFNNAV
     DLIEYITTML VTFMDDHQQL MVDNKGKVLT KQKGCIRVNC LDCLDRTNAF QWCYGWVWLI
     RILESIPLTG YTNTDITIND ARNASRPLKL PEIYKVFWSE YGDAISLFYA GTASTYSSYI
     LQGSNNISVA FNVARTYIER IRSHMLEDQQ RSEAMELILA KHQHKEIVTK CMEDVILSEH
     ADDESASLKI WCGTWNIAGM RMQECDDLQD WLNYGTPRCD IYAFFIQELV ELTTFRVLTN
     WTDPTKEHML EERFKSVLKG FRISYLKIRS ISLLGLCLVI YVKSSLVDSI TNVDVSSIKT
     GLNGNYGNKG AVAVRMRLNS HNLSFVNVHL PPGRSNSNER LEQMDFIIHN IFQDNKPAYR
     LLDRDLVFIG GDFNFRLQIP HDDILKYLCK LNLSTLLEHD EFVNHKKNGV SPFNFMNEQE
     ITFQPSYKFK KNSPFYDLRR SPAWCDRILF FSPIKQQITP LSYKRHERYC SSDHKPISAI
     FQVA
//