ID A0A1R4B3P6_9VIBR Unreviewed; 733 AA.
AC A0A1R4B3P6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Putative tyrosine-protein kinase in cps region {ECO:0000313|EMBL:SJL83521.1};
DE EC=2.7.10.- {ECO:0000313|EMBL:SJL83521.1};
GN ORFNames=VPAL9027_01489 {ECO:0000313|EMBL:SJL83521.1};
OS Vibrio palustris.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1918946 {ECO:0000313|EMBL:SJL83521.1, ECO:0000313|Proteomes:UP000189475};
RN [1] {ECO:0000313|EMBL:SJL83521.1, ECO:0000313|Proteomes:UP000189475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 9027 {ECO:0000313|EMBL:SJL83521.1,
RC ECO:0000313|Proteomes:UP000189475};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; FUFT01000003; SJL83521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4B3P6; -.
DR STRING; 1918946.VPAL9027_01489; -.
DR Proteomes; UP000189475; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SJL83521.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189475};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SJL83521.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..121
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 386..467
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 554..669
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 274..315
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 733 AA; 81362 MW; 9F19BD430ADF4701 CRC64;
MLGEPNFNTT IKIMTDSRSK AVSSTDKDEI DLGQLFGTLL DGKWVIVIVT CLFMLIGVAY
ALLATPIYQS DALIQVEQKS SGGFSSVVSE NLGDMFSSES TADTEIELIR SRMVLGGTVD
KFNLTTVVKP NYIPVIGKGW ARLTDDEQKI KVTQFDIADS YQHEPHEYHI QVINGKQGTY
QLVDDNAQVL LKGRVGATSA GHGFVLKVSD IQADDGFEFS IVKRNRIDAV QWLKTHLSAE
EQGKQTGIIR LSFTSDNADF SEALLDNISQ RYFLQNVERD SAEAEQSIHF LKEKLPQLKA
KLIESENKLN DYRKKRESVD LTMEAESTLK VMVNLDAQLN QLTFKEAEIS QKYTKDHPAY
KSLLDKRQTL LGEKAKLNKK IENLPETQKR ILSLQRDVQV NQQIYVQLLN KVEELNVVKA
GTVGNVRIID HAQTFSDPVK PKKLLVVLIC TILGGLMSVA YVLLRAAMHK GIETPDQIEE
LGLSVYASVP KSELQMNLAE KLKRLRSNTK EMNLLAELNP ADLSIEALRG LRTSLHFAMM
EANNNILMIS GPAPGIGKSF VSTNFAAVYA KTGQRVLLID ADMRKGYLQQ ALGLSNDNGL
SDYLSGKIET EVLVKNTAIE NLDVITRGQV PPNPSELLMH KRLDELLGWA SGQYDLVIVD
TPPVLAVTDA SIVGAKAGTT LMVTRFGVNT AKEIEVARAR FEQSGIEVKG VIFNAIEKKA
SSHYGYGYYN YSY
//
