ID A0A1R4F4G1_9ACTO Unreviewed; 747 AA.
AC A0A1R4F4G1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Integral membrane protein {ECO:0000313|EMBL:SJM50784.1};
GN ORFNames=CZ771_04370 {ECO:0000313|EMBL:SJM50784.1};
OS Actinomycetales bacterium JB111.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales.
OX NCBI_TaxID=1434822 {ECO:0000313|EMBL:SJM50784.1, ECO:0000313|Proteomes:UP000196124};
RN [1] {ECO:0000313|EMBL:SJM50784.1, ECO:0000313|Proteomes:UP000196124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB111 {ECO:0000313|EMBL:SJM50784.1,
RC ECO:0000313|Proteomes:UP000196124};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FUHX01000019; SJM50784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4F4G1; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000196124; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000196124};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 203..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 236..365
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 747 AA; 77293 MW; 1A88D7CE32F4C719 CRC64;
MAPMFTALGR LVTAAPRIVV ACWIVVVAAV GVLAMTPVGG DGLFDRVVGG SEPVVPGSDS
TRAAEAISEH STEADTVTMV VTGIDLADPA VGAAVVEVLG PLTAELSEID GVTGAASPAA
FPGGVDDPQA APFVAAGGDG VAVVATIGTE APMPSVHDAV ERAMRDVDLT ALGDGVDSHV
MSLQLVTDAI NEQIEKDLVT GEAFGLPAAL LIMILVFGGF LAASLPVIGA VASIVLGLGA
LLGLTYATDV ESFVVNVVTV LGLGLSIDYG LLVVSRFREE VALMRAADDG ARIAKGDPRI
AEAVRTTVQT SGRTVVFSAI TVAVSVAGLL FMRPDILTII SLGAVAVILL AVVAAATLTP
ALLMLWGHVL ARGSALERIP GIGRAVRAVS DNSTEEGIFS ALARRVHRRP WWVMGGVAVV
LVVLALPLTH LTLRASTFEM VPEDTDTGLA LAEVSASYPA LDFGDVLVVA DAPAGDVGDL
VAEIGAVDGV ATVRDPAPLG EEQALVVVDL DTDDPGDATG VAVTEEIRDV QAGYETWVGG
RAGSQIDFTD ALVDGFPLTA LVVAVAVFVL LFLMTGSLLV PLKALVINSL SIAASLGLTT
WLLTTTTGSG LIGLDEPHGG LETYVVALVV AFGFGLAMDY EVFLLARIKE YWDRTRDNDL
AVERGLQRSG RIITSAALII IAVFLGFALG EVAAIQQVGI GLALTVLIDA TLVRMLLVPA
TMTLLGRWNW WAPPSLRRVH ERFAIRH
//
