ID   A0A1R4FPV6_9MICO        Unreviewed;       203 AA.
AC   A0A1R4FPV6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=HIT family protein {ECO:0000313|EMBL:SJM57853.1};
GN   ORFNames=CZ674_05750 {ECO:0000313|EMBL:SJM57853.1};
OS   Agrococcus casei LMG 22410.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Agrococcus.
OX   NCBI_TaxID=1255656 {ECO:0000313|EMBL:SJM57853.1, ECO:0000313|Proteomes:UP000195787};
RN   [1] {ECO:0000313|EMBL:SJM57853.1, ECO:0000313|Proteomes:UP000195787}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 22410 {ECO:0000313|EMBL:SJM57853.1,
RC   ECO:0000313|Proteomes:UP000195787};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FUHU01000026; SJM57853.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4FPV6; -.
DR   Proteomes; UP000195787; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd01275; FHIT; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR039383; FHIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR   PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR   Pfam; PF01230; HIT; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195787}.
FT   DOMAIN          66..175
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           160..164
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        162
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT   BINDING         92
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         164
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ   SEQUENCE   203 AA;  22522 MW;  0F30410DE2A6E781 CRC64;
     MTDNPSGLSQ NPEDYPTPDD PSREAGAPTW MSSEIGGVPD EFQRLWTPYR MVYIKSGQMP
     DADACPFCLA PTLADEDGLI VHRGEHAYVI MNLYPYNTGH IMVNPYRHIG TYDQANADEI
     AEIGALTQTA MRVLGETSRC DGFNIGMNQG RIAGAGIADH LHQHIVPRWA LDSNFFPIIA
     KTKAIPRLIE EIRAELQAAW PKD
//