ID A0A1R4FY97_9MICC Unreviewed; 709 AA.
AC A0A1R4FY97;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Enoyl-CoA hydratase / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase / 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:SJM60904.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:SJM60904.1};
DE EC=4.2.1.17 {ECO:0000313|EMBL:SJM60904.1};
DE EC=5.1.2.3 {ECO:0000313|EMBL:SJM60904.1};
DE EC=5.3.3.8 {ECO:0000313|EMBL:SJM60904.1};
GN ORFNames=FM101_06560 {ECO:0000313|EMBL:SJM60904.1};
OS Arthrobacter rhombi.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=71253 {ECO:0000313|EMBL:SJM60904.1, ECO:0000313|Proteomes:UP000195913};
RN [1] {ECO:0000313|EMBL:SJM60904.1, ECO:0000313|Proteomes:UP000195913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B Ar 00.02 {ECO:0000313|EMBL:SJM60904.1,
RC ECO:0000313|Proteomes:UP000195913};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; FUHW01000024; SJM60904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4FY97; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000195913; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Isomerase {ECO:0000313|EMBL:SJM60904.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000313|EMBL:SJM60904.1}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:SJM60904.1};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000195913}.
FT DOMAIN 315..491
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 495..581
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT REGION 681..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 74034 MW; 329E11D554F99245 CRC64;
MTDPSSRPAP RVALSRHDDV VLLTLLAPPV NALGQTARTA IAQALDDVAD LSGVRAVVLT
GTEKAFSAGA DITEFGGSTD GISLPELVDR IESFALPVTA AISGVALGGG LELAMAAHTR
VAHPEALLGL PEITLGLIPG AGGTGRLPRL VGPERALAMI LTGTRVGAAT AEGDGLIDAV
LDGGDFSCAA VAWAASRLDE EPGTGSTPPT RTRDLNRRIA EAAAVPGTIE RLAAPAVRKA
KDPFAARAAV DSLAAGIEQG FDAGAELERE KFLERLASDE SAAGLHLFAA ERASRTPRAI
ATAPGEIAAR DVRRAGVIGA GTMGGGIALA LATAGVPVTV VETSAEALDR GLAQIRATLD
VSVSHGSRSP QRANEQFARI SGSLDYADLA SADLIIEAAF EDLDVKKEIF ARLDAHTSED
AVLATNTSYL DVDALAATTA HPGRVLGMHF FSPANVMELV EIVRGEATET RVLATAVSLA
RRLGKCPVVV GVCHGFVGNR MLEVRARQAE ALLLEGALPG QVDDALTGFG FRMGPFAMAD
LAGLDIGWRN RQAQGTTAAV GDALCEAGRF GQKTGAGFFA YQGRERREDP AVTDIIEAAS
AEQGIERREI DSEEILERLL YPMINEGARI LAEDIAERPG DIDLIWVKGY NWPAYRGGPM
FYAQQIGRAR IADRLRQHAR ATGDPTLEPA PWLTEALPDG QGAPGNGRS
//
