ID   A0A1R4G4Q7_9MICO        Unreviewed;       349 AA.
AC   A0A1R4G4Q7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Hydroxymethylglutaryl-CoA reductase {ECO:0000313|EMBL:SJM63161.1};
DE            EC=1.1.1.34 {ECO:0000313|EMBL:SJM63161.1};
GN   ORFNames=FM112_08985 {ECO:0000313|EMBL:SJM63161.1};
OS   Gulosibacter sp. 10.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Gulosibacter.
OX   NCBI_TaxID=1255570 {ECO:0000313|EMBL:SJM63161.1, ECO:0000313|Proteomes:UP000195931};
RN   [1] {ECO:0000313|EMBL:SJM63161.1, ECO:0000313|Proteomes:UP000195931}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10(10) {ECO:0000313|Proteomes:UP000195931};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661}.
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DR   EMBL; FUIC01000022; SJM63161.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4G4Q7; -.
DR   OrthoDB; 9794902at2; -.
DR   Proteomes; UP000195931; Unassembled WGS sequence.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:SJM63161.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195931}.
SQ   SEQUENCE   349 AA;  38005 MW;  58EF889A14CD138F CRC64;
     MARHDRFTTP IPSSWVGPIR ISGNAIDEEI KVPLATYETP LWPSVGRGAR ISRLVEGGIR
     ATVVDERMTR SSLFVARDAA HAFEAWTAIR DREEELREAV SAQSRFARLI EVHEEIVGNL
     LYIRFAFTTG DASGHNMVTQ AAEKLMSLIL SWELGLEYGS VSGNYCSDKK ATAVNGVLGR
     GRSTVAEILI PHEIVETRLR SSAEKIADIV VRKNLVGSTI AGALRSANAH YANMLLAFYL
     ATGQDAANIV EGSQGITYAE ARPEGLYFSC TLPHLIVGTV GNGKHLEAVE EALQRLGCRE
     DREPGANARR LAAMIAAAVL CGELSLLAAQ TNQGELMRSH IQLERGERN
//