ID   A0A1R4G7A8_9MICC        Unreviewed;       279 AA.
AC   A0A1R4G7A8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Oxidoreductase of aldo/keto reductase family, subgroup 1 {ECO:0000313|EMBL:SJM64061.1};
GN   ORFNames=FM101_08320 {ECO:0000313|EMBL:SJM64061.1};
OS   Arthrobacter rhombi.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=71253 {ECO:0000313|EMBL:SJM64061.1, ECO:0000313|Proteomes:UP000195913};
RN   [1] {ECO:0000313|EMBL:SJM64061.1, ECO:0000313|Proteomes:UP000195913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B Ar 00.02 {ECO:0000313|EMBL:SJM64061.1,
RC   ECO:0000313|Proteomes:UP000195913};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FUHW01000028; SJM64061.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4G7A8; -.
DR   Proteomes; UP000195913; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19071; AKR_AKR1-5-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000195913}.
FT   DOMAIN          22..264
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        55
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         113
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            80
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   279 AA;  30266 MW;  6A95C6C6AA49AF3F CRC64;
     MSENPAAVPL QKLANGAEIP MIGLGTWTMD DTEAGAAVRN AIDVGYRLFD TAENYGNEVG
     IGEGIARSPL ARNEVFLTSK FNAEWHSFDG VRQAWRHSIE QLGVDYIDLL LIHWPNPERG
     TYVDAYKGLA KLLAKGKVRA IGTSNFTQSQ LTELMDATGV VPDVNQIQHS PLWMRADDIA
     FHQRHGIHTQ AWAPLARGGV LEAAPVVEAA TAHQKTPAQV VLRWNLQHGA SPIPKSEDPG
     RMASNLDVFG FELDAAQMSA IDALDGTGDA PVDPMVFGH
//