ID   A0A1R4GB30_9MICO        Unreviewed;      1038 AA.
AC   A0A1R4GB30;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE            EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN   ORFNames=CZ674_10460 {ECO:0000313|EMBL:SJM65389.1};
OS   Agrococcus casei LMG 22410.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Agrococcus.
OX   NCBI_TaxID=1255656 {ECO:0000313|EMBL:SJM65389.1, ECO:0000313|Proteomes:UP000195787};
RN   [1] {ECO:0000313|EMBL:SJM65389.1, ECO:0000313|Proteomes:UP000195787}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 22410 {ECO:0000313|EMBL:SJM65389.1,
RC   ECO:0000313|Proteomes:UP000195787};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC         fragments with terminal 5'-phosphates, ATP is simultaneously
CC         hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC   -!- SIMILARITY: Belongs to the HsdR family.
CC       {ECO:0000256|ARBA:ARBA00008598}.
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DR   EMBL; FUHU01000043; SJM65389.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4GB30; -.
DR   OrthoDB; 9758243at2; -.
DR   Proteomes; UP000195787; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd22332; HsdR_N; 1.
DR   Gene3D; 3.90.1570.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR   InterPro; IPR040980; SWI2_SNF2.
DR   PANTHER; PTHR42927; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR42927:SF1; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF04313; HSDR_N; 1.
DR   Pfam; PF18766; SWI2_SNF2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SJM65389.1};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195787};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT   DOMAIN          286..518
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|SMART:SM00487"
SQ   SEQUENCE   1038 AA;  115088 MW;  CF91CCEEE6BBB52E CRC64;
     MTAMHQELAL QAEIADHLEA HGWLRSENSA GYDKERALYP EDLLGWLAET DAANYAKIVP
     EDASAEARAK GEQRILNRVA KLLATDESHG GGTLNVLRKG FDLPGARSRF SLLQMPPADD
     RNPNLTARYG KNRLRVVQEV VYSTKRADRI DLVLFCNGIA VATIELKTSF TQSLEAAIAQ
     YKTDRHPQGE PLLISGRGAL VHFALSDSEV AMSTHLAGSE TVFLPFNKGH ENGAGNPPVE
     GKARTSYFWE DVLERDAWLS ILAKFIYTNH QKRTDPITGK VTQKTQIRFP RYHQWRAVTR
     LTASAREEGP GHNYLIQHSA GSGKTDSIAW TAHRMASLHT PEGHKVFDGV IVIADRQVLD
     RQLQDAVDQL VNVTGTFQPI TSGTDGSKTQ QLTEALASGV PIIGVTLQTF PYALEEIKKN
     GGVLAGKRFA VIADEAHSSQ TGASSRSLKE LLYLADAPES VDEREAGADQ DALVAMAANV
     DEDKRISFFA FTATPKAKTL ELFGQIGESG KHEPFDLYSM KQAIEEKFIL DVLQNYTTYE
     LAARIALRGA DDEGVDEVDV RKGTRAYIGF VELHPTNVAS KVEVILEHYQ EAVRDELGGR
     AKAMVVTSSR AAAVKYARAF QKAIEQKGLP LKTLVAFSGE VADPDVVALP GTEQKMVTEA
     SMNPALKGRD LASVFAQDDQ NILIVANKYQ TGFDQPLLVA MYVDKPLSGI TAVQTLSRLN
     RMAPGKQNTY VLDFVNDADL ILDAFQEYYE DATIYEESDP DLVADLMVKL DAQSIYTEAE
     VNLVWDEWRT LNGKHTKLGA HLDPAVERFA YRWKAAVYEQ NDEELEVLQD FRSTLAQYVK
     SYAFFSQILH FGDPRYEKLS VFADLLARKL RAFNADDPDA TAVDVDDVVL THFKLEKLRD
     EDLHLQSGET EGLRGMTEAG LAKIREKERS PKTELVEKVN KYFGDLDARD EYKVQFAETL
     LAEALDSDEL RLQALNNSKA DFSNSPKLQI EIEDALWRQD GANGEIQQAA RALSTGRLIE
     LVLELGLYDR LRATGTEG
//