ID A0A1R4GPB0_9GAMM Unreviewed; 751 AA.
AC A0A1R4GPB0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tyrosine-protein kinase ptk {ECO:0000313|EMBL:SJM70019.1};
DE EC=2.7.10.- {ECO:0000313|EMBL:SJM70019.1};
GN Name=ptk {ECO:0000313|EMBL:SJM70019.1};
GN ORFNames=A1232T_00883 {ECO:0000313|EMBL:SJM70019.1};
OS Psychrobacter piechaudii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=1945521 {ECO:0000313|EMBL:SJM70019.1, ECO:0000313|Proteomes:UP000188357};
RN [1] {ECO:0000313|EMBL:SJM70019.1, ECO:0000313|Proteomes:UP000188357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Psychrobacter_piechaudii {ECO:0000313|EMBL:SJM70019.1};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; FUGE01000102; SJM70019.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4GPB0; -.
DR STRING; 1945521.A1232T_00883; -.
DR OrthoDB; 9775724at2; -.
DR Proteomes; UP000188357; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SJM70019.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000188357};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SJM70019.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..111
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 388..468
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 557..708
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 290..382
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 751 AA; 83097 MW; 4347CCA834710792 CRC64;
MSQTVPNPST NDTTQQDDEI DLIALLLTLL RGWKTILACA LLSLALGVTY SRYVQPTYQT
DALLQIDEKS KGVAALGANI SELVGESGSA AETERELIKS RMVLGPVVDK LHLDLRISNP
EIGSLDRIAQ SKIPSQTSTE QGVFLETRHG EAQINNFEVP LAYLNKPFTL VKTATGFTLS
LEINEETIEY KGNIGTPTTL NTPEGNIRIS VASLPAVGHP ISLTKLSTPS AINALGDNLS
VTERGKQTGI VQLTLSGEDQ EQVSRVLSNV VQSYIDQNLS RGAQRTTTTI EFMESQIPQL
KQKLEQSEEA FNKFREQYGT IDVTKEAEIL LSESAQIERQ LSELQLKQAE LLTYYTAEHP
LVVQINDQLA VLNARRQEIK DTVTRMPETQ REFLQLSQDM EINREIYLTM LKNYEQLKIA
RAGEIGSVRV VDMPINTYKA IAPKKLQIWI LALLLGTMLG TLLVFIKSLL RNPVKDPEQL
EAKTGVPVIA TIPRSKTSFN LSKKKHNNRN LLAMVDHEGL SYEAIKSLRT SLIFTMPKLT
KAAQGSIESD TGMIKHGKVI VITGEAPGIG KSFVSSNLAE TFSQLNKKVL IVDGDMRRGE
LHKIFSITKN VGLSDYLTAN EDALNNYIHP TSFDFIDFMP RGEHPTNPAS LLASEKFRSM
MAQLVAIYDI IIIDTPPILA VSDAIITAKY ADKVLMVTRF NQSIEGQVAY AVKQMDKGGV
TVDGIVLNDM VQGITSKYNY HYSYAYGNSK D
//
