ID   A0A1R4H6U5_9GAMM        Unreviewed;       441 AA.
AC   A0A1R4H6U5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Sodium/alanine symporter AgcS {ECO:0000313|EMBL:SJM91741.1};
GN   Name=agcS {ECO:0000313|EMBL:SJM91741.1};
GN   ORFNames=CRENPOLYSF1_200071 {ECO:0000313|EMBL:SJM91741.1};
OS   Crenothrix polyspora.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Crenotrichaceae; Crenothrix.
OX   NCBI_TaxID=360316 {ECO:0000313|EMBL:SJM91741.1, ECO:0000313|Proteomes:UP000195667};
RN   [1] {ECO:0000313|EMBL:SJM91741.1, ECO:0000313|Proteomes:UP000195667}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSM_CP1 {ECO:0000313|EMBL:SJM91741.1};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU363064}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; FUKI01000094; SJM91741.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4H6U5; -.
DR   OrthoDB; 9806926at2; -.
DR   Proteomes; UP000195667; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|RuleBase:RU363064};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195667};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        65..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        97..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        179..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        240..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        345..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        414..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   441 AA;  46777 MW;  0DC7D71B907A066A CRC64;
     MTDSLATLVA TLSSWVWGPP MLTLLVGTGL YLTILLKGLQ FRALPAAFRL VFHKEHGDDG
     DISHFAALMT ALAATVGIGN IVGVATAISV GGPGAVFWMW MTGLVGMVTK YSEAVLAVKY
     REKGEHGMRG GPMYYISKGA GLPWLGWLFA LFTAMATFGI GNMTQANATA KIFEATFHIQ
     PWITGVVLMI LTALVILGGI RSIGKFTSFL VPVMIFGYVG AALVVLALNI AEIPAAFGLI
     FHHAFSPIAA SGGFAGATIA AAMRFGIARG VFSNESGLGS APIAAAAART QDPVKQALVS
     MTQTFIDTLV VCTMTALVIL TATPWTQGIS PGQLTSASFA ETLGATGEII VAVSTSLFAY
     STLIGWNYYG EKAIEYLMGS RAIRIYRIFF IAAVVVGAML NLELVWNISD LMNGMMALPN
     LIGLLLLSKV VKAETDRYFK F
//