ID A0A1R4HUS7_9MICO Unreviewed; 588 AA.
AC A0A1R4HUS7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SJN11295.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:SJN11295.1};
GN ORFNames=FM113_11590 {ECO:0000313|EMBL:SJN11295.1};
OS Leucobacter sp. 7(1).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leucobacter.
OX NCBI_TaxID=1255613 {ECO:0000313|EMBL:SJN11295.1, ECO:0000313|Proteomes:UP000195513};
RN [1] {ECO:0000313|EMBL:SJN11295.1, ECO:0000313|Proteomes:UP000195513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7(1) {ECO:0000313|Proteomes:UP000195513};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; FUID01000061; SJN11295.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4HUS7; -.
DR Proteomes; UP000195513; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SMART; SM00135; LY; 3.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:SJN11295.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000195513}.
FT DOMAIN 6..39
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 49..156
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 162..226
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 588 AA; 62540 MW; C69F6E34205DDF1E CRC64;
MTTSRVAIIG AGVIGLSWAE LFRERGWEVA IYDVSPDAIP TDRGFEIAGS IADAVRGATL
VQENGPERLE IKRSLLADIA AAASEDTIIA SSTSSLLPSL LAEGNERAEQ ILVGHPYNPP
QIMPLVEIVP GPDTRADLVQ AAERIYRDIG KVPVALQREV PGFVGNRVQK AVLDEAMWLV
ANGVVDARDF DVIFQESLGL RWASIGVFEA SHLGGGPAGL RHIIEHVGAA LDAIELHRPE
LTPAAREALV QQVESTYGIA DTYPERAGRR DRITRAVRAT VGSEQRRPVL YALDVLGGSV
NRIDPRSGDT VPLVSGLREA PDGIAVDTSA GAVTFTCMGQ PDGAAATGEE PEFTTRNGSV
QRIPLTGGEP EVIVDRGSFV TGKQLAADPA TGRLYWSDRE GRGIYRAEAD GSGLTQLVDT
RGSGPSEVEE WCVGIAVDAA AGHLYWTQKG NADVGQGRIM RAGIEIPEGE RAATRRDIET
LWHDLPEPID LELDLSAGML YWTDRGAGPD GNTLNRAPIP AAGEPGTTPT VLSRGYREAI
GLALDTIHHV AYVSDLSGVI REVQLGTGVE RVVTTLPGAA TGLALSWE
//