ID   A0A1R4J0W0_9ACTN        Unreviewed;       286 AA.
AC   A0A1R4J0W0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Oxidoreductase, aldo/keto reductase family {ECO:0000313|EMBL:SJN25574.1};
GN   ORFNames=FM114_04785 {ECO:0000313|EMBL:SJN25574.1};
OS   Luteococcus japonicus LSP_Lj1.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Luteococcus.
OX   NCBI_TaxID=1255658 {ECO:0000313|EMBL:SJN25574.1, ECO:0000313|Proteomes:UP000188342};
RN   [1] {ECO:0000313|EMBL:SJN25574.1, ECO:0000313|Proteomes:UP000188342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LSP_Lj1 {ECO:0000313|EMBL:SJN25574.1,
RC   ECO:0000313|Proteomes:UP000188342};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FUKQ01000018; SJN25574.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R4J0W0; -.
DR   STRING; 1255658.FM114_04785; -.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000188342; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19133; AKR_AKR5F1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000188342}.
FT   DOMAIN          26..260
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        52
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         110
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            77
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   286 AA;  31086 MW;  6088069A0B6DC3CA CRC64;
     MTAQQTVTLN NGVEMPLLGF GVFQVPDAAE CERVVSEALE AGYRLIDTAA AYGNEEAVGR
     AIAASGIARD EIFVTTKLWI QDAGEKAARA AFETSLAKLG LDRLDLYLIH QPFNDYYGSW
     RAMEQLLAEG LVRAIGVSNF YPERLVDLAL NASIVPAVNQ VELHPFFQQA DALATMNKLG
     VAPQAWGPFA EGQHGIFTHP VLTRIGEAHG VTAAQVALRW NIQRGVSVLP KSVTSERIKA
     NADVWAFELS ASEMDEVAAL DLGRSEIIDH SSPNTVEMLN GMRIHD
//