ID A0A1R4J1I6_9ACTN Unreviewed; 584 AA.
AC A0A1R4J1I6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Signal peptide peptidase SppA, 36K type {ECO:0000313|EMBL:SJN26020.1};
GN ORFNames=FM114_05020 {ECO:0000313|EMBL:SJN26020.1};
OS Luteococcus japonicus LSP_Lj1.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Luteococcus.
OX NCBI_TaxID=1255658 {ECO:0000313|EMBL:SJN26020.1, ECO:0000313|Proteomes:UP000188342};
RN [1] {ECO:0000313|EMBL:SJN26020.1, ECO:0000313|Proteomes:UP000188342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSP_Lj1 {ECO:0000313|EMBL:SJN26020.1,
RC ECO:0000313|Proteomes:UP000188342};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; FUKQ01000018; SJN26020.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4J1I6; -.
DR STRING; 1255658.FM114_05020; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000188342; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000188342};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 120..249
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 361..511
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 171
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 377
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 584 AA; 62276 MW; B9FE39E128E9EF62 CRC64;
MDLKSLVIDR VLSRTPLAGK VPGGKVVLEI DLGRGLLSHP PETPWAAMKA MNAPTLTTLA
QKLREAAGDE DVAGLVLYAG SAPLTLPQAQ ELGLAIADFG QQKPTLAFAP ALGELSNDLA
SYLLASSCHQ IWLQPSGQLG IGGVHLGITL FKGLLGKAAI EPQFGKRHEY KTAADQFAAD
QVSDANREMM QAIANSFTHD FVDTVAERRG VDRETVWRAV DESPLTPEQA LEWRLVDRVG
YRDEAVAHLL AEWGGDDELK PEQLRFAHRW TPGGPAGQAV TQLNSRRQPT IAVVPVRGGI
VMGRGRPSGM GEPETGADVI AEQLRAASRD DKVKAVVLRV DSPGGSAVAS DTIWRAVHQV
RESGLPVVAQ MGNYAASGGY YVSMGADEIV ALPATLTGSI GVLAGKMVTT GLYDKLGLVH
EAIDSGPNAG MLASDQHFTE EQWARLNAWL DRIYDDFTRK AAADRGMDHA QLEPLARGRV
WTGRDAHERG LVDHLGGLEL AVERACALAG LDRDKVQLKS HAGIGILDRV RPAQSTEQPT
AASLASAWTP EAVLKQLSVR VGLPLSSGIL EIPQISWGSG ATSA
//
