ID A0A1R4J749_9MICO Unreviewed; 344 AA.
AC A0A1R4J749;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=FM104_05670 {ECO:0000313|EMBL:SJN27635.1};
OS Microbacterium esteraromaticum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=57043 {ECO:0000313|EMBL:SJN27635.1, ECO:0000313|Proteomes:UP000196320};
RN [1] {ECO:0000313|EMBL:SJN27635.1, ECO:0000313|Proteomes:UP000196320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B Mb 05.01 {ECO:0000313|EMBL:SJN27635.1,
RC ECO:0000313|Proteomes:UP000196320};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
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DR EMBL; FUKO01000019; SJN27635.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4J749; -.
DR OrthoDB; 9770771at2; -.
DR Proteomes; UP000196320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044119; Adenylation_LigC-like.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR044117; OBF_LigC-like.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SJN27635.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000196320}.
FT DOMAIN 109..231
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 344 AA; 37863 MW; 207B091E1D410FA9 CRC64;
MYEIPAPMLA KAAASIPDPA KRPMLYEPKW DGFRGLIAWD GETLEIGSRG AKPLTRYFPE
LVERLSAILP GPCLLDGEIV VATGPAGAQR LDWEALSQRI HPAASRVAKL ADETPAMFIA
FDLLAEGSED LQPLPFRERR ARLERMLAAA PPPLHLTRTT DDADLARRWL AEFEGAGLDG
VVAKPLDDPY APGKRTLIKI KHARSADVVA LGYRVHKSGS GVGSLLVGLY GDDGVLRQVG
GVAAWTDAMR QQLVKDLAPL VERNAEGQAV TGEGERSRFT GSKDVSFVRL RPERVLEVRY
DQLEGTRFRH TVQFERWRPD RDAASCTYDQ LETVAGYDLA DVLD
//
