ID   A0A1S1JDH7_9FLAO        Unreviewed;       924 AA.
AC   A0A1S1JDH7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=BHE19_02105 {ECO:0000313|EMBL:OHT46323.1};
OS   Flavobacterium tructae.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1114873 {ECO:0000313|EMBL:OHT46323.1, ECO:0000313|Proteomes:UP000180252};
RN   [1] {ECO:0000313|Proteomes:UP000180252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSU {ECO:0000313|Proteomes:UP000180252};
RA   Chen S., Walker E.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHT46323.1}.
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DR   EMBL; MIKE01000011; OHT46323.1; -; Genomic_DNA.
DR   RefSeq; WP_070906106.1; NZ_MUHG01000002.1.
DR   AlphaFoldDB; A0A1S1JDH7; -.
DR   STRING; 1278819.BHE19_02105; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000180252; Unassembled WGS sequence.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          585..778
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   924 AA;  104600 MW;  88D9A5B865C625EC CRC64;
     MDRFSFLNAA HTEFFAQLYD QYLVNPDSVE PSWRSFFQGF DFGQTTYNDE NPVQRIVEYV
     TNDNVDCSLV SDKLQKEFNV LKLIDAYRTR GHLFTKTNPV RDRRTSSPTL DIENFGLTTA
     DLSTVFDAAQ AIGVAPSTLQ DIVTRLQTIY CQHIGIEYMY IRNPGVVKWI QDKLAVNVNQ
     PNFSSDEKKT ILNKLNQAVS FENFLHTKYV GQKRFSLEGG ESIIPALDAL IEQAAEKGVE
     QFVMGMAHRG RLNVLANIFG KSTQDIFGEF DGKDYDQEYF DGDVKYHLGL TADKKTRTGK
     NININLAPNP SHLETVGAVI EGITRAKQDK YYPNDFSKVL PIAVHGDAAI AGQGILYEII
     QMSLLDGYKT GGTIHIVINN QVGFTTNYLD ARSSTYCTDV AKVTLSPVLH VNADDAEAVV
     HAVSFALDYR MQFGRDVFID LLGYRKYGHN EGDEPRFTQP VLYKIIAKHK NPRDIYAEKL
     LSDGIIDASY VNALEKEYKS ALEENLEASR KKDLTIITPF MQNEWNGFVQ VTDTQMLEKT
     DTTFEKKELD SIINTISTLP ADKKFINKIT KIVTDRKVGY DNNTLDWGTA EALAYGSLLT
     EGFDVRISGQ DVERGTFSHR HAVVKVEDSE EEVILLDTIA NKKGKFGVFN SLLSEYGVLG
     FDYGYALANP NALTIWEAQF GDFSNGAQIM IDQYISCGED KWNNQNGIVL LLPHGYEGQG
     AEHSSARMER YLQLCARHNM YVADCTTPAN FFHLIRRQMK TKFRKPLVVF SPKSLLRDPR
     CVSTVEELAN GSFQETIDDT TVNKKDVKSL VFCTGKFYYD IVAERENNGR NDVAVVRIEQ
     LFPFPVEQIK EIIAQYPNAD DYVWAQEEPK NMGAYSFMLM NFDLVKWRLA SLKAYSAPAS
     GSYTRSKRRH ADAIRMVFDK NLFR
//