ID A0A1S1NHC7_9MYCO Unreviewed; 138 AA.
AC A0A1S1NHC7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN Name=vapC2_1 {ECO:0000313|EMBL:PQM46955.1};
GN Synonyms=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN ORFNames=BKN37_19740 {ECO:0000313|EMBL:OHU99103.1}, C1Y40_02875
GN {ECO:0000313|EMBL:PQM46955.1};
OS Mycobacterium talmoniae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1858794 {ECO:0000313|EMBL:OHU99103.1, ECO:0000313|Proteomes:UP000179734};
RN [1] {ECO:0000313|EMBL:OHU99103.1, ECO:0000313|Proteomes:UP000179734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MO-5499 {ECO:0000313|EMBL:OHU99103.1}, and NE-TNMC-100812
RC {ECO:0000313|Proteomes:UP000179734};
RA Greninger A.L., Elliott B., Vasireddy S., Vasireddy R.;
RT "Genome sequence of Mycobacterium talmonii.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PQM46955.1, ECO:0000313|Proteomes:UP000238296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2683 {ECO:0000313|EMBL:PQM46955.1,
RC ECO:0000313|Proteomes:UP000238296};
RX PubMed=28809146; DOI=10.1099/ijsem.0.001998;
RA Davidson R.M., DeGroote M.A., Marola J.L., Buss S., Jones V., McNeil M.R.,
RA Freifeld A.G., Elaine Epperson L., Hasan N.A., Jackson M., Iwen P.C.,
RA Salfinger M., Strong M.;
RT "Mycobacterium talmoniae sp. nov., a slowly growing mycobacterium isolated
RT from human respiratory samples.";
RL Int. J. Syst. Evol. Microbiol. 67:2640-2645(2017).
RN [3] {ECO:0000313|EMBL:PQM46955.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC BAA-2683 {ECO:0000313|EMBL:PQM46955.1};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An RNase.
CC {ECO:0000256|HAMAP-Rule:MF_00265}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|HAMAP-Rule:MF_00265};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC {ECO:0000256|ARBA:ARBA00038093, ECO:0000256|HAMAP-Rule:MF_00265}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHU99103.1}.
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DR EMBL; MLQM01000131; OHU99103.1; -; Genomic_DNA.
DR EMBL; PPEA01000415; PQM46955.1; -; Genomic_DNA.
DR RefSeq; WP_071028658.1; NZ_MLQM01000131.1.
DR AlphaFoldDB; A0A1S1NHC7; -.
DR Proteomes; UP000179734; Unassembled WGS sequence.
DR Proteomes; UP000238296; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd18755; PIN_MtVapC3_VapC21-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR HAMAP; MF_00265; VapC_Nob1; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR022907; VapC_family.
DR PANTHER; PTHR33653; RIBONUCLEASE VAPC2; 1.
DR PANTHER; PTHR33653:SF1; RIBONUCLEASE VAPC2; 1.
DR Pfam; PF01850; PIN; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00265};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00265};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00265};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00265};
KW Reference proteome {ECO:0000313|Proteomes:UP000179734};
KW Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649, ECO:0000256|HAMAP-
KW Rule:MF_00265}.
FT DOMAIN 21..122
FT /note="PIN"
FT /evidence="ECO:0000259|Pfam:PF01850"
FT BINDING 7
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
FT BINDING 97
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
SQ SEQUENCE 138 AA; 15123 MW; A56A2A731DDE2E99 CRC64;
MSGWLIDKSA YTRLARSLDP ALWANRIERG LVRVTAATRL EMGWSARSVD DLRYEIANPP
LARMPLVYLT PAIEDRAIEV QFLLAARGHH RAVSVPDLLI AAAAELSGLT VLHLDKDFDL
VAATTGQPVE RLELAAAP
//
