ID A0A1S1NK59_9MYCO Unreviewed; 334 AA.
AC A0A1S1NK59;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component {ECO:0000313|EMBL:PQM49135.1};
DE EC=1.14.15.30 {ECO:0000313|EMBL:PQM49135.1};
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:OHV04854.1};
GN Name=hmp_2 {ECO:0000313|EMBL:PQM49135.1};
GN ORFNames=BKN37_08185 {ECO:0000313|EMBL:OHV04854.1}, C1Y40_00645
GN {ECO:0000313|EMBL:PQM49135.1};
OS Mycobacterium talmoniae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1858794 {ECO:0000313|EMBL:OHV04854.1, ECO:0000313|Proteomes:UP000179734};
RN [1] {ECO:0000313|EMBL:OHV04854.1, ECO:0000313|Proteomes:UP000179734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MO-5499 {ECO:0000313|EMBL:OHV04854.1}, and NE-TNMC-100812
RC {ECO:0000313|Proteomes:UP000179734};
RA Greninger A.L., Elliott B., Vasireddy S., Vasireddy R.;
RT "Genome sequence of Mycobacterium talmonii.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PQM49135.1, ECO:0000313|Proteomes:UP000238296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2683 {ECO:0000313|EMBL:PQM49135.1,
RC ECO:0000313|Proteomes:UP000238296};
RX PubMed=28809146; DOI=10.1099/ijsem.0.001998;
RA Davidson R.M., DeGroote M.A., Marola J.L., Buss S., Jones V., McNeil M.R.,
RA Freifeld A.G., Elaine Epperson L., Hasan N.A., Jackson M., Iwen P.C.,
RA Salfinger M., Strong M.;
RT "Mycobacterium talmoniae sp. nov., a slowly growing mycobacterium isolated
RT from human respiratory samples.";
RL Int. J. Syst. Evol. Microbiol. 67:2640-2645(2017).
RN [3] {ECO:0000313|EMBL:PQM49135.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC BAA-2683 {ECO:0000313|EMBL:PQM49135.1};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHV04854.1}.
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DR EMBL; MLQM01000029; OHV04854.1; -; Genomic_DNA.
DR EMBL; PPEA01000096; PQM49135.1; -; Genomic_DNA.
DR RefSeq; WP_071024277.1; NZ_MLQM01000029.1.
DR AlphaFoldDB; A0A1S1NK59; -.
DR Proteomes; UP000179734; Unassembled WGS sequence.
DR Proteomes; UP000238296; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0036200; F:3-ketosteroid 9-alpha-monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00207; fer2; 1.
DR CDD; cd06214; PA_degradation_oxidoreductase_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006058; 2Fe2S_fd_BS.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR008333; Cbr1-like_FAD-bd_dom.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR47354; NADH OXIDOREDUCTASE HCR; 1.
DR PANTHER; PTHR47354:SF5; PROTEIN RFBI; 1.
DR Pfam; PF00970; FAD_binding_6; 1.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00409; PHDIOXRDTASE.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00197; 2FE2S_FER_1; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022714};
KW Monooxygenase {ECO:0000313|EMBL:PQM49135.1};
KW Oxidoreductase {ECO:0000313|EMBL:PQM49135.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000179734}.
FT DOMAIN 5..107
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT DOMAIN 246..334
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
SQ SEQUENCE 334 AA; 35282 MW; F95917DA6B1D9CB0 CRC64;
MAITHVFQQA TVTRIIKETA DARTFVLAPR EAPFSYRAGQ YCTFRVQVDG EELYRSYSMS
SAPETDTELM TTVKRVPGGK VSNWMLDNVV EGDELTMTRA AGTFCLDAAA VPVLGFAGGS
GITPLLSLAK SALAGTDRTV RLLCADRDAA SAIFDAALAE LAARHPGRLS VRRHLDADDG
LLDAAAVREF VGADTGADCY VCGPEGFMTV VRSALPGPGR VFVEDFDLPA PKEPAAATAE
TADATGTVTI HLERKKVSVP RVAGETLLES ARRAGLAPPF SCEAGNCGTC MAHISEGSAT
MRVNDALDDD EVADGYILTC QGVPDTASIT VHYE
//
