ID A0A1S1Q0T8_9ACTN Unreviewed; 1905 AA.
AC A0A1S1Q0T8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OHV27590.1};
GN ORFNames=BCD49_38710 {ECO:0000313|EMBL:OHV27590.1};
OS Pseudofrankia sp. EUN1h.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC Pseudofrankia.
OX NCBI_TaxID=1834515 {ECO:0000313|EMBL:OHV27590.1, ECO:0000313|Proteomes:UP000179465};
RN [1] {ECO:0000313|Proteomes:UP000179465}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EUN1h {ECO:0000313|Proteomes:UP000179465};
RA Ghodhbane-Gtari F., Swanson E., Gueddou A., Morris K., Hezbri K., Ktari A.,
RA Nouioui I., Abebe-Akele F., Thomas K., Gtari M., Tisa L.S.;
RT "Sequence Frankia sp. strain EUN1h.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHV27590.1}.
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DR EMBL; MBLN01000126; OHV27590.1; -; Genomic_DNA.
DR RefSeq; WP_071042548.1; NZ_MBLN01000126.1.
DR Proteomes; UP000179465; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..457
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1520..1598
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 401..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1796..1815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1905 AA; 197490 MW; 9072982DFB5D45FC CRC64;
MSDEQKLREY LKRATVELHD ARGRLEKAEA ARSEPIAIIG MACRFPGGVR SPEDLWDFLL
AGADAITDFP ADRGWAVPDP FIDPLGRPGA RAVRTGGFLP DVAEFDAEFF GISPREALAM
DPQQRLLLET SWEALERAGI DPKALRGTDT GVFAGRVTED YALVVADPSS EIEPYRLTGL
AGSVLSGRVS YFLGLEGPAV TVDTACSTSL VALHLALGAL RRRECSLALV GGATVLATPD
AFTDLGRRGV LSPDGRVRPF AXGADGTALA EGVGVIAIQL LSEARRDGHP VLAVVXGSAV
NQDGGPDGSA ARARRLVVEQ ALADARLTAA EVDAVEAHGD STVSGDLAEA TALAAAYGQG
RPGDRALLVG TVKSRLGHTL AAAGLAGVIH TVTALRHGEL PPTLHDADPP SPWIDWDGGP
LAPLTRRTPW PSTGRPRRAG VSAFGITGTN AHVILEQAPA APAAPDELDE STPVRDPEPE
AASPPPRPVS LPLSLSGAGG PALRAQAARL RAFLAGDPSP APADVGLSLA VTRSALAHRA
VVLGADRTEL TAGLDAVARG EPGPNAVTGV ARERGKTVFV FPGQGTQWPG MALGLLDTNP
VFAQHLRDCA AVIEQYVPWK VEAVLRAAPD APPITRIDVL QPVILALNIA LARLWQHHGI
HPDAVIGHSQ GEAAAAHISG ALTLDDAARV IITRSRLFAD HLAGHGAVAS IQLPAHDLTH
HLDQHPDQLW IAGVNSPAAT TVAGDLEALD ALVDALTARG IRARVIPDTV ASHSPRVQPL
RDLLLRELAF LKPRPAAIPQ YXTTHPDTLL AGTELTADYW YDNCRNPVNF APTIHTLLDQ
GHHTYLEIGT HPVLTAAIEH TAETHPAAAA ILTLNTLRRG DGGPERLNTA LAEAWTNGLP
VDWRPAFAGT AARRVDLPTY AFRRRRYWFE PSSAAVPRVA DGSALTALWD AVDDGDESGA
AQALRLRGES GTGALRELLP ALTAWRRDRR IRATLASWHY RTAWRPLPEP DAGMVAGDWL
LVAPAAAGPA DTADVDAVAA ALIRHGARVP RIDVDPHDPD AQRLATRLKE AGAAKAAGVV
SLLATAGDSR DPAADGMPGA AVAGTVTLLR ALAILGTEAR LWSLTRGAVS TGPRDPLRSP
AQAQIWGLGQ TAALESPALW GGLIDLPACL DARSGSRLAL LLAAARRAEG GERELAVRDT
GAFARRLVRA AADWAGSPAD GRGDPGRSRP GWSTSGTALV TEGLTATGTH VARWLARAGA
RHLVLTSAGR PDPDRAAVLA AELAALGVGS TILEADPADR EALLRALAAV PADLPLTTVV
HTADPRGEGA LEDVTPAQLG QVLAPKAAAA WQLHSLTRDR GLSAFVLFST LAGTLGSALG
LGGYGAAGAY LDALATYRAA QGLPASSVAW GVWSDADAPE REEADRAARL ARRGIPPLDP
ETALAALDGV LARGETTALV ADLRWPDYLA AHGAVAPGAL LAEIPEVAAA RRPTTASGVP
DGPAAPDTFL AGLAELTPAR QREALLGLVT REIAAVLGHQ ATTAVDPTSL FIELGFDSLT
SVELRNRLAA ATGARLTVRV ILEHGTPDAL TAWLRADLFP ASAADPAAGP GTGTGSPAPE
PVPAPETSVG PGLIAPLFRR AREAGRTAEF VRFLTGLAAY RPSFGAPPEE HDLPRVVRLA
RGAEGRPALF CFPSPLGGAA PEQFTRFAEH FDGGHDVFAF ALPGFHAGER VPRTLDAVAE
AAAAALGRQA EPGAAVLVGH AAGGLLAHAV AARLEAAGSP AAGLVLLDTA AVTAAELDSP
GAPHPDGGPL GQPEDEAWLT ALGAYAPLLT GPAPGPVRTP TLLVRAAGGA AGPSWPAAHR
VVRAPGDRLS LLEQHAEATA RLVRPWLAAP APVGTATGET KEHLA
//
