ID   A0A1S1Q5A7_9ACTN        Unreviewed;       282 AA.
AC   A0A1S1Q5A7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:OHV30068.1};
GN   ORFNames=BCD49_34930 {ECO:0000313|EMBL:OHV30068.1};
OS   Pseudofrankia sp. EUN1h.
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC   Pseudofrankia.
OX   NCBI_TaxID=1834515 {ECO:0000313|EMBL:OHV30068.1, ECO:0000313|Proteomes:UP000179465};
RN   [1] {ECO:0000313|Proteomes:UP000179465}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EUN1h {ECO:0000313|Proteomes:UP000179465};
RA   Ghodhbane-Gtari F., Swanson E., Gueddou A., Morris K., Hezbri K., Ktari A.,
RA   Nouioui I., Abebe-Akele F., Thomas K., Gtari M., Tisa L.S.;
RT   "Sequence Frankia sp. strain EUN1h.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHV30068.1}.
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DR   EMBL; MBLN01000093; OHV30068.1; -; Genomic_DNA.
DR   RefSeq; WP_007512504.1; NZ_MBLN01000093.1.
DR   AlphaFoldDB; A0A1S1Q5A7; -.
DR   Proteomes; UP000179465; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR   PANTHER; PTHR30136:SF35; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   4: Predicted;
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          21..83
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51077"
FT   DOMAIN          84..273
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000259|PROSITE:PS51078"
SQ   SEQUENCE   282 AA;  29551 MW;  109D459B3C329F63 CRC64;
     MASNGTGAPA TPDGDPIAST SQALERGLSV LSALGAERAP LGLVEISRAV GLSKSTCHRY
     MATLVSLGFV EQDAGTRRYA LGPQALQLGF AALSSLELSK VAARPLQTLA DETGHTANMA
     VLDGADIVYI ERRRPTRAAF RIELNIQVGA RLPAYCTSMG KVLLAYRDPA TVRAILDRTD
     LARRGPKTVT AREQLTTILA KVVADGLAVN DEELAPGLRS IAAPVRDRSG QAVAAVNISV
     HLGAWNASME AVARRLEGPL RRTAGEISSR LGYLGTLDGS GG
//