ID   A0A1S1Q8J2_9ACTN        Unreviewed;       705 AA.
AC   A0A1S1Q8J2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=CC117_26950 {ECO:0000313|EMBL:OHV31168.1};
OS   Parafrankia colletiae.
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC   Parafrankia.
OX   NCBI_TaxID=573497 {ECO:0000313|EMBL:OHV31168.1, ECO:0000313|Proteomes:UP000179627};
RN   [1] {ECO:0000313|Proteomes:UP000179627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cc1.17 {ECO:0000313|Proteomes:UP000179627};
RA   Ghodhbane-Gtari F., Swanson E., Gueddou A., Morris K., Hezbri K., Ktari A.,
RA   Nouioui I., Abebe-Akele F., Simpson S., Thomas K., Gtari M., Tisa L.S.,
RA   Hurst S.;
RT   "Sequence Frankia sp. strain CcI1.17.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHV31168.1}.
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DR   EMBL; MBLM01000147; OHV31168.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1S1Q8J2; -.
DR   OrthoDB; 3196525at2; -.
DR   Proteomes; UP000179627; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000179627}.
FT   DOMAIN          239..517
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         260..267
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   705 AA;  77307 MW;  739DCE98B0CDA0F7 CRC64;
     MASLGFAQSF FRRLPDLPKE VQKRIPELLG RFQESTIAGL HLEKPHALAD DRGRTIRVTK
     FWRGVVMAPV EGDHYILFDV LEHDRAYVWL ANHTFAINSA TREVEIVDVE AMRNVSKSLP
     SVAGDLRPGA FDAYGNTVLL ELGIEAVHLP LVRRVRADTD LDLLSRAMPH SQHEVLEMLA
     AGYSVREVRA ELGIRSSVVS REPDPSVAAL ASPTVFVPQS ARELQEALEH PLELWRIFLH
     PTQRRIAYRE KFAGPVRVTG GAGTGKTVVA LHRAHHLARR LPEKHGRPVL VTTFVRTLAE
     GLRAGLASLD AVTGADTSSA VEVTTVDALA HRIVTEVEGA APKIVLDDDS LTKIWTAATA
     ATGAPFTPAM LRQEWENVIL ARGVRTPMDY LSAPRAGRIQ PLTRTQRLQV WTAVEYFLGV
     LGDSGERTFH QLADDAAQYV RSGAAGDLFP HVVVDEAQDL HPVQWRLLRA VVADGPDDLF
     VVGDAHQRIY DHRVALTAMG INVRGRSHRL RLNYRTSEEI LTWAVALLNG QVVDDLDGGL
     DHLDGYRSAF RGVQDPTAHG YLTAAAELDG LVSTIRGWLD GGVEPAAIGV AARTRRMADD
     ATDALRAAGI EPSPLDRRKR GGVEIGTMHR MKGLEYRAVA VVDVSARSVP LPQAVTSQTV
     EATLHVQDLQ RELCLLHVAC TRAREFLAVS WSGAPSPFLK MILEA
//