ID   A0A1S1QBB9_9ACTN        Unreviewed;       801 AA.
AC   A0A1S1QBB9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Erythronolide synthase {ECO:0000313|EMBL:OHV30382.1};
GN   ORFNames=CC117_27535 {ECO:0000313|EMBL:OHV30382.1};
OS   Parafrankia colletiae.
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC   Parafrankia.
OX   NCBI_TaxID=573497 {ECO:0000313|EMBL:OHV30382.1, ECO:0000313|Proteomes:UP000179627};
RN   [1] {ECO:0000313|Proteomes:UP000179627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cc1.17 {ECO:0000313|Proteomes:UP000179627};
RA   Ghodhbane-Gtari F., Swanson E., Gueddou A., Morris K., Hezbri K., Ktari A.,
RA   Nouioui I., Abebe-Akele F., Simpson S., Thomas K., Gtari M., Tisa L.S.,
RA   Hurst S.;
RT   "Sequence Frankia sp. strain CcI1.17.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000256|RuleBase:RU003694}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHV30382.1}.
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DR   EMBL; MBLM01000153; OHV30382.1; -; Genomic_DNA.
DR   RefSeq; WP_071089653.1; NZ_MBLM01000153.1.
DR   OrthoDB; 3202594at2; -.
DR   Proteomes; UP000179627; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000179627};
KW   Transferase {ECO:0000256|RuleBase:RU003694}.
FT   DOMAIN          30..450
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   REGION          443..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          572..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   801 AA;  83027 MW;  7F08A886EF274E10 CRC64;
     MTASADRLLE ALRATMKENE RLRRQLAATS EPIAIIGMAC RFPGGPRTLR SPDDLWRFVT
     VGGDAISGFP DNRGWDTSSL PCFGGGFLHD AADFDPEFFG MSENDALATD PQQRLLLETS
     WEAFEHAGID PRTARGSSTG VYFGVIFHDY GYRLRPPPPG IDGYTYFGSA GSIASGRVSY
     TLGLEGPCVT LDAACASSLV GLHLASQALR RGECTLALVG GVSVLATTEL WEETTRQGQG
     LAPDSRCKSF AAAANGTGIS EGVGVLLVER LGDARRNGHP VHAVVRGSAV DQSGATNGFT
     APSAASQERL ITRALADAGL TPDDVDAVEG HGTGTPVGDP IELAALHATY GRGRRPDRPL
     YLGSLKSNLG HTQAAGGAGA IIKAALAMRH GTLPRTLHVD APTPHADWSD GTIALLTQPQ
     PWPATDGRPR RIGVSSFGAN GTLAHAILEQ PPADPADELP TGPSTGSSAE PAVGPALDVV
     PWLLSARSAA GLRGQAERLL TRLTERPELA PVDVAYSLAT GRSALEHRAV LVARDSAAFR
     RGLAALAAGS DPEATGPDAF ASASTVTVTR GAAGAEGTGL PTSDGSTSGP PLVLVFPDQP
     DALAGTGSAL AGRFPAFAAA LRTVGPAPDE PSRAVWTGFA VQVALARLLE SWGVRPDVRL
     GQGSGEIAAA YLTGTLTLDD ARALISAPPS PAPSSGPIPW DVHRIPANAM TVIVGRPVPD
     GEPSAGSDTG PVEGGRAADL VLLPPDRVEI RAVTELLAAL HTRGTPVDWH AFFAGTGARR
     VDLPTYAFQR RXFWLEPATA P
//