ID   A0A1S1R490_9ACTN        Unreviewed;       388 AA.
AC   A0A1S1R490;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Prephenate/arogenate dehydrogenase domain-containing protein {ECO:0000259|PROSITE:PS51176};
GN   ORFNames=BCD49_08480 {ECO:0000313|EMBL:OHV40589.1};
OS   Pseudofrankia sp. EUN1h.
OC   Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC   Pseudofrankia.
OX   NCBI_TaxID=1834515 {ECO:0000313|EMBL:OHV40589.1, ECO:0000313|Proteomes:UP000179465};
RN   [1] {ECO:0000313|Proteomes:UP000179465}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EUN1h {ECO:0000313|Proteomes:UP000179465};
RA   Ghodhbane-Gtari F., Swanson E., Gueddou A., Morris K., Hezbri K., Ktari A.,
RA   Nouioui I., Abebe-Akele F., Thomas K., Gtari M., Tisa L.S.;
RT   "Sequence Frankia sp. strain EUN1h.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHV40589.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MBLN01000014; OHV40589.1; -; Genomic_DNA.
DR   RefSeq; WP_007509299.1; NZ_MBLN01000014.1.
DR   AlphaFoldDB; A0A1S1R490; -.
DR   Proteomes; UP000179465; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          47..364
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
FT   REGION          102..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  39811 MW;  4E3630F5F3A17346 CRC64;
     MTMHARLVDL VAVTTPDPDA ASPAVPTTPT SAADLVDAAD LADLAGLRVL VVGTGLIGTS
     VGMALRRHGT DVLLYDRYPA QSAVAARRGA GRVWPFPGPR QAGLAGPRPV DAADAGARGA
     QADDPAADAG DPAASAGQAV DHVVIAVPPR DVGHTLVAWQ RLLPGATFSD TASVKVEPLT
     DAERLGADMS RICGAHPVAG RERGGPEWAV ADLFANRPWV ITPSAATSRL AQRHASLMAV
     GCGAWVAHLD PRTHDFALGL LSHLPHIVAS AFAARLATMP EDLARLAGPG LMDFTRIAGA
     NADLWTEIVG ANASPLADLL ADVVADLDRV RDALGAGAVQ GSGTDPVVES LFRMGNTGRC
     RLEAAKALPA PRTAIDDHIG GVDGRMSA
//