ID A0A1S1V8U6_9FIRM Unreviewed; 581 AA.
AC A0A1S1V8U6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Malate-2H(+)/Na(+)-lactate antiporter {ECO:0000313|EMBL:OHW63016.1};
GN Name=mleN_1 {ECO:0000313|EMBL:OHW63016.1};
GN ORFNames=EUAN_08000 {ECO:0000313|EMBL:OHW63016.1};
OS Andreesenia angusta.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Gottschalkiaceae;
OC Andreesenia.
OX NCBI_TaxID=39480 {ECO:0000313|EMBL:OHW63016.1, ECO:0000313|Proteomes:UP000180254};
RN [1] {ECO:0000313|EMBL:OHW63016.1, ECO:0000313|Proteomes:UP000180254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1989 {ECO:0000313|EMBL:OHW63016.1,
RC ECO:0000313|Proteomes:UP000180254};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Eubacterium angustum.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHW63016.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MKIE01000002; OHW63016.1; -; Genomic_DNA.
DR RefSeq; WP_071062151.1; NZ_MKIE01000002.1.
DR AlphaFoldDB; A0A1S1V8U6; -.
DR STRING; 39480.EUAN_08000; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000180254; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000180254};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010362813"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..200
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT DOMAIN 201..551
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 581 AA; 62276 MW; 67F32149B28FE44E CRC64;
MKDRIRLDFS KVLALSLSLA LLIPVSAFAE GADESSVNAI KFGIFTLIPP VVAITLAFIS
KNVVLSLFVG VLSGTFMLEL SGANVLMALF RGIMNLIQKL LDSLADPWNA GIVLQVLTIG
GLIGLVSRMG GARAIAESLA KRAKTPRSAQ IITWLLGLVV FFDDYANALI VGPIMRPVTD
KMNVSREKLS FIIDGTAAPI AGIALVSTWI GYELSLIRDG YELIGQTVNP YGVFISTIPY
RFYNIFMLAF IFMGIVLLRE FGPMYKAEKR ARTEGKLLRD DANPMVSSEI EALEPKEGIK
LSVWNAIIPI GVLMIGSLLG FYYDGYQAIS SGGDMALLEA IRQSPVSFFA VRETFGAADA
SIVLFQSALI ASIVAMIMGV SQKIFVLGEA IDVWISGMKS LIITGVILLL AWSLSGTIKE
LGTAVYLINI LQDAPESVLQ SLNFLLPAII FILGSVISFA TGTSYGTMGI LMPLAIPLAF
SINPDQGYVV MSVGAVLTGA IFGDHCCPIS DTTILSSMGA ACDHIDHTRT QLFYSLVVAA
ISVVVGYILV GLGVSVWIAL ALGFATLLLI LRIFGKTVDI K
//
