ID A0A1S1XZQ1_9GAMM Unreviewed; 645 AA.
AC A0A1S1XZQ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Macrolide ABC transporter permease/ATP-binding protein MacB {ECO:0000313|EMBL:OHX34642.1};
GN ORFNames=BJL95_19140 {ECO:0000313|EMBL:OHX34642.1};
OS Methylomonas sp. LWB.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomonas.
OX NCBI_TaxID=1905845 {ECO:0000313|EMBL:OHX34642.1, ECO:0000313|Proteomes:UP000180009};
RN [1] {ECO:0000313|EMBL:OHX34642.1, ECO:0000313|Proteomes:UP000180009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LWB {ECO:0000313|EMBL:OHX34642.1,
RC ECO:0000313|Proteomes:UP000180009};
RA Stephenson J., Kumaresan D., Hillebrand-Voiculescu A.M., Murrell J.C.;
RT "Draft genome sequence of the methane oxidising bacterium Candidatus
RT Methylomonas sp. LWB isolated from Movile Cave.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC exporter (TC 3.A.1.122) family. {ECO:0000256|ARBA:ARBA00038388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHX34642.1}.
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DR EMBL; MKMC01000067; OHX34642.1; -; Genomic_DNA.
DR RefSeq; WP_071160525.1; NZ_MKMC01000067.1.
DR AlphaFoldDB; A0A1S1XZQ1; -.
DR Proteomes; UP000180009; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB-like_ATP-bd.
DR InterPro; IPR025857; MacB_PCD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR30572:SF14; MACROLIDE EXPORT ATP-BINDING_PERMEASE PROTEIN MACB; 1.
DR PANTHER; PTHR30572; MEMBRANE COMPONENT OF TRANSPORTER-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:OHX34642.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000180009};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 268..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..245
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 645 AA; 68696 MW; F9DC4C16BD766EEB CRC64;
MNQTPLLQLT DIQRVYPNGD ATVRALDGVS LTIWPGEFVA IVGQSGSGKS TLMNLIGCLD
RADAGAYRVL GRDVADLDPD QLAALRRDSF GFVFQRYNLL NTATATENVE IPALYAGLPK
LERRRRALQL LSKLGLAERG EHRPMQLSGG QQQRVAIARA LINDPPVILA DEPTGALDSH
SGMEVMSLLG NLHAEGRTVL LITHDEKIAA HAQRVIHIAD GKIVGDGEAH IGGSAVPPPA
HPGIGGAGLA AELGEAAKTA LRSLRVNLFR TALTLLGIVI GVAAVVTMLA VGQGSQEKVL
EQMRAMGTDI LSIRPGLPGF RGGGDVATLT LADTDAIAEL ANVASAAPER NGRMTVRYAS
VDYATSVQGV ASSMPWVRDW PIALGDFFDE RDQRRYAPVV VLGETVRKLL FAEGEDPLGR
FVMIGNIPFE VIGVMATKGA DAQGSDRDDA VFVPITTGLT RLFGQKYLGG VTVRVEDVVK
IDATQQAITD LLIARHQTED FRIRNMASII ESATETQNTF TLMLGIVAAI SLLVGGIGVM
NIMLVSVTER TREIGIRIAT GARRRDILLQ FNTEAAVVCT LGGFMGVLLG FAAGYVLKYF
EMAVLFSPLP AILAFSCAFG TGVLFGYLPA RKAAFLDPVV ALAAE
//
