ID A0A1S1Y1D2_9GAMM Unreviewed; 1088 AA.
AC A0A1S1Y1D2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Chemotaxis protein CheR {ECO:0000313|EMBL:OHX35295.1};
GN ORFNames=BJL95_01775 {ECO:0000313|EMBL:OHX35295.1};
OS Methylomonas sp. LWB.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomonas.
OX NCBI_TaxID=1905845 {ECO:0000313|EMBL:OHX35295.1, ECO:0000313|Proteomes:UP000180009};
RN [1] {ECO:0000313|EMBL:OHX35295.1, ECO:0000313|Proteomes:UP000180009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LWB {ECO:0000313|EMBL:OHX35295.1,
RC ECO:0000313|Proteomes:UP000180009};
RA Stephenson J., Kumaresan D., Hillebrand-Voiculescu A.M., Murrell J.C.;
RT "Draft genome sequence of the methane oxidising bacterium Candidatus
RT Methylomonas sp. LWB isolated from Movile Cave.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHX35295.1}.
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DR EMBL; MKMC01000045; OHX35295.1; -; Genomic_DNA.
DR RefSeq; WP_071159836.1; NZ_MKMC01000045.1.
DR AlphaFoldDB; A0A1S1Y1D2; -.
DR Proteomes; UP000180009; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0008984; F:protein-glutamate methylesterase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16434; CheB-CheR_fusion; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.40.50.180; Methylesterase CheB, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR035909; CheB_C.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000673; Sig_transdc_resp-reg_Me-estase.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01339; CheB_methylest; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF00989; PAS; 2.
DR Pfam; PF13596; PAS_10; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF52738; Methylesterase CheB, C-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50122; CHEB; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Chemotaxis {ECO:0000256|PROSITE-ProRule:PRU00050};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00050};
KW Reference proteome {ECO:0000313|Proteomes:UP000180009}.
FT DOMAIN 7..196
FT /note="CheB-type methylesterase"
FT /evidence="ECO:0000259|PROSITE:PS50122"
FT DOMAIN 199..472
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 847..917
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 974..1043
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT COILED 642..711
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 19
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
FT ACT_SITE 46
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
FT ACT_SITE 138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
SQ SEQUENCE 1088 AA; 123781 MW; D7000744B60FD9E2 CRC64;
MKTPNDKKEP QYVVGIGASA GGLEAIESFF KKMPPDTGMA FIVVQHLSPD YKSLMVELLS
KHTLMPVLRI EEGMKVEPNH VYLIPPRKNL TMFHGHLLLN NQNHTNELNL PIDIFMRSLA
EDVSEFAVGI ILSGTGSDGT RGIRAIKEHG GMVMVQDEES AKFDGMPRNA IATGLVDFIM
PPEDMPKQLM AFVKHPYAVQ EATIHSEDSD LTRIFALLRD KHKVDFTFYK PNTIVRRIER
RISINQCRDL KEYRNLLEDN SQEVSALFQE LLIGVTNFFR DDFVFEEIRG KWLTPLVKSL
TNNEIRIWIA GCSTGEEAYS LAIMLAEYRE YSGHFFRMKL FATDVDAKAV EKASTGLYPE
SIAADVPSHL LVKYFSRKED SFQISQSIRE MVVFAQHNLI KDPPFTNIHL LSCRNLLIYL
QPVLQKKILE LFNFSLVKDG LLMLGTSESI GEMVDYFDMI SPKGKIYRAR GKYRTLGISS
MDPPPALMTS FRANSPQSGR NFANRYQDDK ILERFFNALT KDILPFTMIV NENMEISHIF
GDAQRYLSYP SGKLVTDITK LVSKDLSIPI ATGVRKALKS GDSINMSNIK LREKDKARTL
NIHIRLLPGR KSQETLIAIL IFEADHHATQ DIGFVADNFD INQDAAQRIN DLEHELQLTR
ENLQATVEEL ETSNEELQAT NEELLASNEE LQSTNEELQS VNEELYTVNA EHQSKITELT
ILNNDLDNLF NSTNIGILFL DENLDIRRFT HKLQSLFHIV ENDIGRPFFH LTHSIRDIDL
EDLIGKVVEK KIILESEVQN QHGNWYFMRI IPYAVSDRIY SGVILTFVDI DLLKQTQLSL
RQQTELETQR LASFVNDSAD AITLLDDTGK FITWNRGAEN LYGWSSQEAL QMRFESLVPL
AERPRMRGVF DKLQQGEQVT QFDSKRLNRH GEVIDVSVSA TLLSSQNDAG QIFALTERDL
RSHLLIDKRH CISCIQKLAT LLMDVDEAII VIDFEGSIVA WNTGAESLYG WSRSEAIGMK
FDSLVPDYLR TEAREMFQSI TSGKSNYQVT QSQRLTRNKQ ILDITMIASV LGYQDGDTIL
VVTTEKPV
//
