ID A0A1S2DA56_9GAMM Unreviewed; 992 AA.
AC A0A1S2DA56;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:OHY98727.1};
GN ORFNames=BC443_06935 {ECO:0000313|EMBL:OHY98727.1};
OS Salinicola sp. MIT1003.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Salinicola.
OX NCBI_TaxID=1882734 {ECO:0000313|EMBL:OHY98727.1, ECO:0000313|Proteomes:UP000179615};
RN [1] {ECO:0000313|EMBL:OHY98727.1, ECO:0000313|Proteomes:UP000179615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT1003 {ECO:0000313|EMBL:OHY98727.1,
RC ECO:0000313|Proteomes:UP000179615};
RA Biller S.;
RT "Membrane vesicles in seawater: heterogeneous DNA content and implications
RT for viral abundance estimates.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHY98727.1}.
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DR EMBL; MCAP01000055; OHY98727.1; -; Genomic_DNA.
DR RefSeq; WP_071232596.1; NZ_MCAP01000055.1.
DR AlphaFoldDB; A0A1S2DA56; -.
DR STRING; 1882734.BC443_06935; -.
DR OrthoDB; 9811557at2; -.
DR Proteomes; UP000179615; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2190; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000179615}.
FT DOMAIN 33..263
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 992 AA; 108792 MW; 1150CB61AD0199AA CRC64;
MSEFESRLRR ELKGEVAFDA GSRGRYATDA SIYQIMPLGV VVPKDQEDLA LALDIARDVG
APVLPRGGGT SQCGQTVNEA LVIDTSRWLT GIGDLDVEAR TVTVEPGVVL DHLNAWLKPH
GLWFPVDVST SAQCTLGGMA GNNSCGSRSI RYGNMVHNVL GLEATLADGR EANFGFLDEI
GPGSTLAGLA DSVSAIIHRE AAAIREHYPQ VLRRVGGYNL DLFDCRNPIP YDAEGRANFA
HLLIGSEGTL AFTRRLKLKL SPLPVHKVLG VVNFPTFYQA MDMTQHIVKL GPAAVELVDR
TMIELALENP AFRPTVEKSL IGRPDALLLV EFAGEERDSQ LRQLEALKTL MGDLSLPDSV
VGLETGAEQS ALWNVRKAGL NIMMSMKGDG KPVSFIEDCA VPLEHLAEYT EQLTDVFHRH
GTEGTWYAHA SVGTLHVRPI LDMRRGGAAK MRAIAEEASE LVRRYKGAYS GEHGDGICRG
EWVAWQFGAE LNAAFGEIKR LFDPDNRFNP NKIVDTPKMD DARLFRFPSD HQIIPVATEL
DWSAWDVTRD PLSGELGEPG SGGDPAHGLA KAVEMCNNNG HCRKFDAGTM CPSYRISRDE
RHLTRGRANT LRLVLSGKIG DQGLASDEVA EALDLCVSCK GCKRDCPTGV DMAKFKIEAR
AARAKERGLG WRDKLVSELP RYAPWMRHVG GVASRLERVT WLGGRAKRWL GFAEARSLPV
FSGDYLRAAR HETPASVTAG EVVLFVDTFN NYFEADNASA ARRVLEAADY RVHFNVREGE
RPLCCGRTYL AAGRVDRARQ EARRTLDALM PFVARGVKIV GLEPSCLLTL RDEFLHYGFD
DEGFGDEARR LAEAAMLFEE FLVAEKQAGR LNLALEPLAV SRAKVHGHCH QKAFDAFTPV
MTVLNWIPDL EVEAIVSSCC GMAGSFGYEA EHIEASQQMA ELSLLPAVRE AGEDAWIVAD
GTSCRHQILD GAGREALHVA KVLEAALRHQ KK
//
