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Database: UniProt
Entry: A0A1S2DDN5_9GAMM
LinkDB: A0A1S2DDN5_9GAMM
Original site: A0A1S2DDN5_9GAMM 
ID   A0A1S2DDN5_9GAMM        Unreviewed;       437 AA.
AC   A0A1S2DDN5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 7.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=BC443_12480 {ECO:0000313|EMBL:OHZ01228.1};
OS   Salinicola sp. MIT1003.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Salinicola.
OX   NCBI_TaxID=1882734 {ECO:0000313|EMBL:OHZ01228.1, ECO:0000313|Proteomes:UP000179615};
RN   [1] {ECO:0000313|EMBL:OHZ01228.1, ECO:0000313|Proteomes:UP000179615}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT1003 {ECO:0000313|EMBL:OHZ01228.1,
RC   ECO:0000313|Proteomes:UP000179615};
RA   Biller S.;
RT   "Membrane vesicles in seawater: heterogeneous DNA content and
RT   implications for viral abundance estimates.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OHZ01228.1}.
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DR   EMBL; MCAP01000022; OHZ01228.1; -; Genomic_DNA.
DR   RefSeq; WP_071231757.1; NZ_MCAP01000022.1.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000179615; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000179615};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000179615};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      355    431       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       9     16       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    203    203       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     103    103       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     188    188       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   437 AA;  46993 MW;  5B62BD9F3E1B376D CRC64;
     MDPVRVGICG LGTVGGGTFD VLTRNADEIA RRAGRPIVIE QVGARRDNPD CDTSGVKVTR
     DIFEVARNPD IDVLVELIGG YDVARELVMT AIEHGKHVVT ANKALIAVHG NEIFQAAHKK
     GVIVAFEAAV AGGIPVIKSL REGLGANRIQ WLAGIINGTG NYILTHMRDE GRAFEDVLAE
     AQALGYAEAD PTFDVEGIDA AHKLTILASI AYGVPLQFDR AYTEGIARIT AEDVEQADNL
     GYTIKHLGIT RRGDNGVELR VHPTLIPKER LLANVHGVKN AIAVMGDAVG PTLYYGAGAG
     AEPTASAVVA DLLDVARNIA TAHRYRVPYL AFSGINDEAN ALPILPMEEI VTAYYLRLLA
     VDRPGVLARV ATILSEQTIS IEAIIQKEAT EGELVPIILL THRTREQHMN DAIRQLESLA
     DIAGPVTRIR VESLDEQ
//
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