ID   A0A1S2LYK9_9BACI        Unreviewed;       488 AA.
AC   A0A1S2LYK9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Sodium:alanine symporter {ECO:0000313|EMBL:OIJ17310.1};
GN   ORFNames=BKP37_02045 {ECO:0000313|EMBL:OIJ17310.1};
OS   Anaerobacillus alkalilacustris.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Anaerobacillus.
OX   NCBI_TaxID=393763 {ECO:0000313|EMBL:OIJ17310.1, ECO:0000313|Proteomes:UP000179524};
RN   [1] {ECO:0000313|EMBL:OIJ17310.1, ECO:0000313|Proteomes:UP000179524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18345 {ECO:0000313|EMBL:OIJ17310.1,
RC   ECO:0000313|Proteomes:UP000179524};
RA   Bassil N.M., Lloyd J.R.;
RT   "Draft genome sequences of four alkaliphilic bacteria belonging to the
RT   Anaerobacillus genus.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIJ17310.1}.
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DR   EMBL; MLQR01000001; OIJ17310.1; -; Genomic_DNA.
DR   RefSeq; WP_071308036.1; NZ_MLQR01000001.1.
DR   AlphaFoldDB; A0A1S2LYK9; -.
DR   OrthoDB; 9804874at2; -.
DR   Proteomes; UP000179524; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF7; SODIUM_PROTON-DEPENDENT ALANINE CARRIER PROTEIN YRBD-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        17..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        92..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        171..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        204..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        231..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        295..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        355..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        390..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        420..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   488 AA;  52257 MW;  0296041EDC1C061F CRC64;
     MEQAVNWLNG ILWSDPVIYI CLAVGLLFSV LTRFLQVRHI KEMVKLMFQG KSSKAGISSF
     QAMSIALSGR VGTGNIAGTA TAIAFGGPGA VFWMWAIAFI GASSAFVEST LAQIYKVKQD
     GQYRGGPAYY IEKGIGSKWF AVAFALSALL AMSVLLPGTQ SNSIATGLKN AFNITPNVTG
     IILVVIIGLI IFGGVKRIAN VAQLVVPFMA LAYILISFVI IAMNISELPG VLSLIFKSAF
     GADAAFGGMI GMAISWGVKR GIFSNEAGQG TGPHAAAAAE VSHPAKQGLV QAFSVYIDTL
     LVCSATAFMI LFTGMYNTVG ADDTIIYRGL AGVEPGPGYT QAAIESALPG FGSSFVGIAL
     FFFAFTTIMA YYYIAETNIA YLTFGKNNKL PMFLLKVVLL FATYYGAIRK ADLAWTLGDI
     GVGLMVWLNL IAILLLAKPA LVALKDYEKQ KKQGLDPVFN PEKLGIKNAD YWVNEYDKNN
     NDKEKLTS
//