ID A0A1S2MXE4_9MICO Unreviewed; 337 AA.
AC A0A1S2MXE4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:OIJ34609.1};
GN ORFNames=BK819_03800 {ECO:0000313|EMBL:OIJ34609.1};
OS Microbacterium sp. LCT-H2.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1914306 {ECO:0000313|EMBL:OIJ34609.1, ECO:0000313|Proteomes:UP000179624};
RN [1] {ECO:0000313|EMBL:OIJ34609.1, ECO:0000313|Proteomes:UP000179624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCT-H2 {ECO:0000313|EMBL:OIJ34609.1,
RC ECO:0000313|Proteomes:UP000179624};
RA Huang B.;
RT "Draft genome sequence of strain LCT isolated from the Shenzhou X
RT spacecraft of China.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ34609.1}.
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DR EMBL; MODW01000001; OIJ34609.1; -; Genomic_DNA.
DR RefSeq; WP_071327923.1; NZ_MODW01000001.1.
DR AlphaFoldDB; A0A1S2MXE4; -.
DR OrthoDB; 4324715at2; -.
DR Proteomes; UP000179624; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12167; 2-Hacid_dh_8; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 47..328
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 121..297
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 337 AA; 35506 MW; 72CBC7A4FFA4FAE2 CRC64;
MTAGTSAPTV VAACSAELFA EFFSAEDAAR LETVAARLGG TFARVDRLAD AVLDEARVVV
TSWGVGPFDH AVLATLPKLE LIAHTGATIK PFATDALFDR GVRVTQAGAG MARSVAEVSL
TFTLALLHRV PEMHDALRAG DGWWDAEAVG VQHEILGAPV AVIGASRTGR AYLDLLRALG
AEPLLVDPTL DAAEASSLGA ELVTLDEALR RAQIVAVHAP TLPETHHLIG ARELALMPDG
AGLVNTARSW LVDEAALLAE LRRGRLSAAI DVFDEEPLSA ESPFRSAPRV LLTPHRAAGT
REGRLRQGRI VADELDAFAA GRPLVHAVDR AQLSSMA
//
