ID A0A1S2NTW0_9ACTN Unreviewed; 1864 AA.
AC A0A1S2NTW0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
DE Flags: Fragment;
GN ORFNames=BIV24_29570 {ECO:0000313|EMBL:OIJ84983.1};
OS Streptomyces colonosanans.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428652 {ECO:0000313|EMBL:OIJ84983.1, ECO:0000313|Proteomes:UP000179935};
RN [1] {ECO:0000313|EMBL:OIJ84983.1, ECO:0000313|Proteomes:UP000179935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 93 {ECO:0000313|EMBL:OIJ84983.1,
RC ECO:0000313|Proteomes:UP000179935};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 93.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ84983.1}.
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DR EMBL; MLYP01000105; OIJ84983.1; -; Genomic_DNA.
DR STRING; 1428652.BIV24_29570; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000179935; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000179935}.
FT DOMAIN 451..526
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1519..1594
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OIJ84983.1"
SQ SEQUENCE 1864 AA; 200898 MW; CE6F559A23555B34 CRC64;
WLPVALLAVV KTGAAYLPVD PEYPAERIAY MLGDADPVCV LGSAQTLQQV PEKWTERAVD
VPAQPLDGYS DGELTADERG GELLSEYPVY VIYTSGSTGR PKAVVFRAGA MANLLAWHRG
DRASSGITAH FTSISFDVAA QEIFSTLWSG GTLAVPRDDV RRNPVELVRW LDRHGVNQLH
APNLVIEAVA EAATELDLPL PRLREVAQGG ETLTVRDSVR DFFARVPGRR LHNHYGPTET
HGVTALALEG DARLWPVLPS IGRPLVNSRV YVLDDRLCPV PVGVAGELYL AGDQVARGYL
KQPGLTGERF VADPFAQWAG ERMYRTGDLA RWRADGTVEF LGRADFQVKI RGFRVELGEI
EAVVAGHPLV SQVAVVARED RPGDKRLVAY VIPCEAEAFD ASELRRYAWE RLPDFMVPAA
VVTLAELPLT ANRKLDRRAL PAPEYTASGR GPRGGQEEVL CAVFAEVLGV ERVGIDDNFF
DLGGHSLLAT RVISRVRALL GVELPLRVLF EGPTVAQLAE RVADAGAART ALAPMDRPAE
VPLSFAQRRL WFLNRFEGGT ASAYNLPIAL RVTGAVDQAA LRAAIRDVIA RHESLRTVFP
EGADGTPFQR VLNVDDACPT LLAVPLSEAE LPHALADETQ RGFDLASEPP LRACLFAVDN
TAHVLVVVLH HIAGDGWSMA PLARDVARAY AARTEGRAPA WEPLPVQYAD YAMWQRELLG
DETDPDSVLS RQVAYWKNHL AELPEQLQLP VDRARSATAS YRGDHVAFTL DADTHAGLAE
LARESGASMF MVVQAAFAAL LSRMGAGTDI PIGSPVAGRT DEALDDLVGF FVNTLVLRTD
LSGDPTFREL VGRVREVDLA AYAHQDVPFE YLVEVLNPAR STSRHPLFQV MLTFQNTEQA
EVRLDGLAVA AEATRATTAK FDLSLSVRET RGPDGTPAGL VGTFEFAMDL FDRVTAEQIS
ERLGRLLAAA VANADRPVSG LDILSAHEYE ELVGGAQSPD AGTDARTLPD LFEEQAARVP
EATAVVLDGA ELTYAELNAR ANRLARYLIG HGAGPETTVA LVLPRSADAV VAMLAVLKTG
AAYVPVDPRY PAERIAHMLE DARPTAVLTS AAQGESMPQG RVIVLEDVAE DIAREASADV
PDTARHRPLL PGHPAYLVYT SGSTGRPKGV VVAHETVTGH LWWMARTYPL DATDKVLART
SFSFDAAVWE IWLPLLTGAA MHLVSADVAA DPHQLADQLA RHGVTVVQVV PSLLSELCAA
AVAAGTTQTS LRRLFVGGEP LPAALAELAR DTWGVPCVNL YGPTESTVQV THHQVRDDRT
GTDACVPVGR PVPGVRAYVL DDGLRPVPAG IPGELYLAGG QLARGYAGRP GLTADRFVAD
PYGPPGARMY RTGDLMRRRR GSELEFLGRV DEQVKLRGFR VELGEIEAAL TAQWQISQAA
VVLREDRPGD QRLVAYVIPA DGALLDLDEL RGCLAGLLPD FMVPTVFAVL EAFPLSPNGK
LDRRALPRPD VTARSAGRAP RNPQEEALCG LFAEVLGTTG VGIDDDFFAL GGHSLLATRL
ISRIKTVFGV RVSLRALFEA PTVARLLQRF DGEDPGDGLA QLMPLRPDGD RPPLFCVHPA
SGLSWAYVGM LQHLHPDQPV YGLQARGIAE ERALPCSLAE MAADYAAQMR AVQPTGPYHL
LGWSFGAIAA HAVATTLQEQ GESVAFLGLL DGYPPSGIDM DETDIPDEAG ILQALLRDMG
IQDELRGAAV PPLVKAAELL RHQGGALTGL DEKTLARVVA VCANGMRISA NHRPEVFRGD
VEFFTATAGR PDRQGAHTLW APYVEGHITD HPVDCAHADM TTGEPLKEIS EVVTAKLTGN
GGVQ
//
