ID A0A1S2NWU8_9ACTN Unreviewed; 444 AA.
AC A0A1S2NWU8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:OIJ85686.1};
GN ORFNames=BIV24_28185 {ECO:0000313|EMBL:OIJ85686.1};
OS Streptomyces colonosanans.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428652 {ECO:0000313|EMBL:OIJ85686.1, ECO:0000313|Proteomes:UP000179935};
RN [1] {ECO:0000313|EMBL:OIJ85686.1, ECO:0000313|Proteomes:UP000179935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 93 {ECO:0000313|EMBL:OIJ85686.1,
RC ECO:0000313|Proteomes:UP000179935};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 93.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ85686.1}.
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DR EMBL; MLYP01000085; OIJ85686.1; -; Genomic_DNA.
DR RefSeq; WP_071369280.1; NZ_MLYP01000085.1.
DR AlphaFoldDB; A0A1S2NWU8; -.
DR STRING; 1428652.BIV24_28185; -.
DR OrthoDB; 3564840at2; -.
DR Proteomes; UP000179935; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000179935};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 3..71
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 444 AA; 47675 MW; 2F6FBD4FE5595842 CRC64;
MRPPSYKAVV EEFAASIRAG TLPAGTRLPT HRDLARERRI ALATATRVYA ELAAMGLVVG
ERGRGMFVRV QSGYDGLEPS RALPVPRVAD LSFNQPLGEG QADRLRQALH ALSVSGEIEA
LLRQDPPGGR LHERAAVATY LLERGIDTAP ANVLLTSGAQ QALDSVLRSL TRPGDVLAVD
ALSYPGIKLL ASAHGLDLAP IPVMATGPDL AALDRLCCTR PVRAIYAIPT LHNPLGWVLD
QERRDRLVSI ARSHDCLIVE DGTYAFLESS PPPPLRTLAP ERTCYIAGLS KNVAPGLRFG
FAVLPGHHVE TVTRSLRMAA WGAPGLITAL ATGWLADGTV ARWEEDRRGD AAARQDIARA
ALAGMHLTAH PISYMVWLSL EPHQRPDHVA ALLAEAGILV STADAFATGT HRPRALRLAL
ATPPRDELGT VLQRLRDVID AIPP
//
