ID A0A1S2PC54_9ACTN Unreviewed; 405 AA.
AC A0A1S2PC54;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OIJ91429.1};
GN ORFNames=BIV24_15955 {ECO:0000313|EMBL:OIJ91429.1};
OS Streptomyces colonosanans.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428652 {ECO:0000313|EMBL:OIJ91429.1, ECO:0000313|Proteomes:UP000179935};
RN [1] {ECO:0000313|EMBL:OIJ91429.1, ECO:0000313|Proteomes:UP000179935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 93 {ECO:0000313|EMBL:OIJ91429.1,
RC ECO:0000313|Proteomes:UP000179935};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 93.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ91429.1}.
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DR EMBL; MLYP01000041; OIJ91429.1; -; Genomic_DNA.
DR RefSeq; WP_071366973.1; NZ_MLYP01000041.1.
DR AlphaFoldDB; A0A1S2PC54; -.
DR STRING; 1428652.BIV24_15955; -.
DR OrthoDB; 3204099at2; -.
DR Proteomes; UP000179935; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000179935};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OIJ91429.1}.
FT DOMAIN 8..266
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 275..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 385
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 405 AA; 43331 MW; D91635A4858D51DA CRC64;
MPRTVRDVVF VDGVRTPFGK AGPKGIYHET RADDLVVKAI RELLRRNPGL DPKKVDEVAI
AATTQIGDQG LTIGRTAGIL AGLPTSVPGY SIDRMCAGAL TAVTAVSGSI AFGAYDVAIA
GGVEHMGRHP MGEGVDPNPR FVSEKLVDES ALFMGMTAEN LHDRYPQITK QRADEYAVRS
QERAAKAYAN GKIQQDLVPI SVRRTSPEGG ETGWGLVTAD EPMRPGTTLE NLANLKTPFR
VHGRVTAGNA AGLNDGATAS VIASEEFARE MGLPVKMRLV SYAFVGVEPE IMGYGPIPAT
EKALAKAGLS ISDIGLFEIN EAFAVQVLAF LDHYGIADDD ERVNQYGGAI AFGHPLASSG
VRLMTQLARQ FEEQPEVRYG LTTMCVGFGM GATVIWENPH FEGDK
//
