ID   A0A1S2PQ36_9ACTN        Unreviewed;       507 AA.
AC   A0A1S2PQ36;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=BIV24_09845 {ECO:0000313|EMBL:OIJ95034.1};
OS   Streptomyces colonosanans.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1428652 {ECO:0000313|EMBL:OIJ95034.1, ECO:0000313|Proteomes:UP000179935};
RN   [1] {ECO:0000313|EMBL:OIJ95034.1, ECO:0000313|Proteomes:UP000179935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC 93 {ECO:0000313|EMBL:OIJ95034.1,
RC   ECO:0000313|Proteomes:UP000179935};
RA   Lee L.-H., Ser H.-L., Law J.W.-F.;
RT   "Genome sequence of Streptomyces sp. MUSC 93.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIJ95034.1}.
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DR   EMBL; MLYP01000025; OIJ95034.1; -; Genomic_DNA.
DR   RefSeq; WP_071365840.1; NZ_MLYP01000025.1.
DR   AlphaFoldDB; A0A1S2PQ36; -.
DR   STRING; 1428652.BIV24_09845; -.
DR   OrthoDB; 5318045at2; -.
DR   Proteomes; UP000179935; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000179935}.
FT   DOMAIN          3..278
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          435..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..507
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         24..31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   507 AA;  55491 MW;  DF47CFC7D249B143 CRC64;
     MNPTDEQTAA ADAFHAGHHL ALQAGAGTGK TTTLAFLARA TTRRGRYLAY NRAIAQDART
     RFPNTVQCKT AHALAYAAVG HRYTRRLNAP RRPAWQTGQA LGLTKAIRIG DREISQRALS
     NAALRTVTRF CHTADETITR HHVPRLRGLD DPDLHTQLAT HLVPFACKAW ADLQHPDDGA
     VRFDHDHYLK IWALTRPRIP ADFLLLDEAQ DTNPVVEQIF LAQREHAQLI MVGDSAQAIY
     HWRGAQDVMT GFDGTHLTLS QSFRFGPDLA AEANRWLRLA DAPIRLTGTP VVPTELGPVT
     HPDAVLCRTN VGAMAQVMTL MAAGYRVALA GGGDSLQALA LAARDLKEGR RTHHPELILF
     PSWGDLQDYA AHDPAGRDLQ PLVNLVDTYG TEAILTAVAN LAPEPHAQVT VSTAHKAKGR
     EWSRVLIADD FARLKDNTPD EQTGPPPTPD PIDDAEARLA YVAVTRTRQR LDLGGLSWIH
     DHPDGPSAGH DRPRPPALPQ PPDAART
//