ID A0A1S2PWS3_9ACTN Unreviewed; 431 AA.
AC A0A1S2PWS3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Metal-dependent phosphohydrolase {ECO:0000313|EMBL:OIJ98269.1};
GN ORFNames=BIV23_30430 {ECO:0000313|EMBL:OIJ98269.1};
OS Streptomyces monashensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678012 {ECO:0000313|EMBL:OIJ98269.1, ECO:0000313|Proteomes:UP000179642};
RN [1] {ECO:0000313|EMBL:OIJ98269.1, ECO:0000313|Proteomes:UP000179642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 1 {ECO:0000313|EMBL:OIJ98269.1,
RC ECO:0000313|Proteomes:UP000179642};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 1.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ98269.1}.
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DR EMBL; MLYO01000055; OIJ98269.1; -; Genomic_DNA.
DR RefSeq; WP_071384197.1; NZ_MLYO01000055.1.
DR AlphaFoldDB; A0A1S2PWS3; -.
DR OrthoDB; 9802066at2; -.
DR Proteomes; UP000179642; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR037522; HD_GYP_dom.
DR PANTHER; PTHR45228:SF1; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186; 1.
DR PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR Pfam; PF13487; HD_5; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51832; HD_GYP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:OIJ98269.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000179642};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 220..415
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
FT DOMAIN 242..364
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 431 AA; 46640 MW; 11C00B4B41075E6E CRC64;
MEAVPARARG FVAAVAVLVL LCLLPLPTVR TPWWALALLC ALYAGCEYVV RRRFGGTFHP
VLLAAAFLLP PPAAALVPLP AALLCPVEQR PALLRRVWRA AQPALAVWGA ATVHWTLGGR
DAVVTSDFPY ALLPAGAAVL AFCLILTALD GGILAVAERV PLRRAWRGLL SHSLAPVAVQ
GLAGLMMAVL WRSPYGPVAA LLVLLPMYVS WWVFAQYHRE RAAHQATIRA LVQAVDIKDG
YTRGHSERVG QASVLIAREL GMDDERIEVL RFAGILHDVG KLGVPTRLLR KEGPLTPEER
RVIELHPEYG HEMVRGISFL GEARAAILHH HERLDGSGYP YGLAGERIPE AARVVAVADA
FDAMTSTRSY SRARPVETAL AELERCAGAQ FDPRMVGALV RALRRHGWHP AVTADEAHAP
VRAVAGGGTP R
//
