ID A0A1S2PYJ7_9ACTN Unreviewed; 370 AA.
AC A0A1S2PYJ7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=BIV23_29460 {ECO:0000313|EMBL:OIJ98918.1};
OS Streptomyces monashensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678012 {ECO:0000313|EMBL:OIJ98918.1, ECO:0000313|Proteomes:UP000179642};
RN [1] {ECO:0000313|EMBL:OIJ98918.1, ECO:0000313|Proteomes:UP000179642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 1 {ECO:0000313|EMBL:OIJ98918.1,
RC ECO:0000313|Proteomes:UP000179642};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 1.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000256|ARBA:ARBA00010892, ECO:0000256|RuleBase:RU362101}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ98918.1}.
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DR EMBL; MLYO01000053; OIJ98918.1; -; Genomic_DNA.
DR RefSeq; WP_071384039.1; NZ_MLYO01000053.1.
DR AlphaFoldDB; A0A1S2PYJ7; -.
DR OrthoDB; 9776706at2; -.
DR Proteomes; UP000179642; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR NCBIfam; TIGR00802; nico; 1.
DR PANTHER; PTHR31611; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR PANTHER; PTHR31611:SF0; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000179642};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 28..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 287..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
SQ SEQUENCE 370 AA; 39640 MW; 2B94E648C7BCA39D CRC64;
MTLPEGVPET AAPSPSFRWR REDTLRTAGL MAVIAALHVV AFGVLLLLVV PRHYEVGTKA
FGVGLGITAY TLGMRHAFDA DHIAAIDNTT RKLMADGKRP VSVGFWFALG HSSVVVVMAA
LVAGGARLAG TLMNDGSRTH QVLGTVGTTV SGGFLYLIAA LNLVALVGIA RVFTAMRAGR
YDETELEAHL DSRGFMNRIL GRLTKSVRRP GQMFPLGFLF GVGFDTTTEV LLLALAGNGA
AAGLPWYAVL CLPLLFAAGM SLFDTLDGTF MNFAYQWAFS NPVRKVFYNL TITGLSIAVA
FFVGTIELVG VLHDKLGLSD DVTGWIAGLD LDNVGYVIVG LFVVVWALAI GYWRLAKVEE
RWNARAADAG
//