ID A0A1S2QFE0_9ACTN Unreviewed; 679 AA.
AC A0A1S2QFE0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Short-chain dehydrogenase {ECO:0000313|EMBL:OIK04196.1};
GN ORFNames=BIV23_18640 {ECO:0000313|EMBL:OIK04196.1};
OS Streptomyces monashensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678012 {ECO:0000313|EMBL:OIK04196.1, ECO:0000313|Proteomes:UP000179642};
RN [1] {ECO:0000313|EMBL:OIK04196.1, ECO:0000313|Proteomes:UP000179642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 1 {ECO:0000313|EMBL:OIK04196.1,
RC ECO:0000313|Proteomes:UP000179642};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 1.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK04196.1}.
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DR EMBL; MLYO01000031; OIK04196.1; -; Genomic_DNA.
DR RefSeq; WP_071382005.1; NZ_MLYO01000031.1.
DR AlphaFoldDB; A0A1S2QFE0; -.
DR OrthoDB; 9774430at2; -.
DR Proteomes; UP000179642; Unassembled WGS sequence.
DR CDD; cd08943; R1PA_ADH_SDR_c; 1.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001303; Aldolase_II/adducin_N.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR InterPro; IPR013454; Bifunc_RhaD/ADH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR NCBIfam; TIGR02632; RhaD_aldol-ADH; 1.
DR PANTHER; PTHR43669; 5-KETO-D-GLUCONATE 5-REDUCTASE; 1.
DR PANTHER; PTHR43669:SF8; SHORT-CHAIN TYPE DEHYDROGENASE_REDUCTASE-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF00596; Aldolase_II; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM01007; Aldolase_II; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000179642}.
FT DOMAIN 9..211
FT /note="Class II aldolase/adducin N-terminal"
FT /evidence="ECO:0000259|SMART:SM01007"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 71791 MW; 38E70C24AA74B447 CRC64;
MTSHPEAAAL LSRSRRLGSD PRNTNYAGGN ASAKGTATDP VTGGDVELMW VKGSGGDLGT
LTEDGLAVLR LDRLRALVDV YPGVEREDEM VAAFDYCLHG KGGAAPSIDT AMHALVDAPH
VDHLHPDSGI ALACAADGEK LTAECFADSV VWVPWRRPGF QLGLDIAAVK AAHPRAVGCI
LGGHGITAWG DTSEECERNS LHIIRTAEQF LAERGRAEPF GPLVEGYGAL PEAERRARAA
ALAPYVRALA SQDRPQVGHF DDADVVLDFL ARAEHPRLAA LGTSCPDHFL RTKVRPLVLD
LPPAAPLQEA VARLKELHAA YREEYAAYYA RHALPDSPAL RGADPAIVLI PGVGMFSFGR
DKQTARVAGE FYVNAVNVMR GAEAVSAYAP IEESEKFRIE YWALEEAKLR RMPRPKPLAT
RVALVTGGGS GIGKAIARRL VAEGACVVVA DLDTDNAAAV AEELGGPDKA VAVTVDVTDE
EQIAAAFRTA VLAFGGVDLV VNNAGISISK PLLETSVRDW DLQHDIMARG SFLVSREAAR
VMIAQGLGGD VVYIASKNAV FAGPNNIAYS ATKADQAHQV RLLAAELGEH GIRVNGVNPD
GVVRGSGIFA GGWGAQRAAV YGVPEEKLGE FYAGRTILKR EVLPEHVASA VLALTGGDLT
HTTGLHIPVD AGVAAAFLR
//
