ID A0A1S2QFI2_9ACTN Unreviewed; 784 AA.
AC A0A1S2QFI2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Family 65 glycosyl hydrolase {ECO:0000313|EMBL:OIK04844.1};
GN ORFNames=BIV23_15980 {ECO:0000313|EMBL:OIK04844.1};
OS Streptomyces monashensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678012 {ECO:0000313|EMBL:OIK04844.1, ECO:0000313|Proteomes:UP000179642};
RN [1] {ECO:0000313|EMBL:OIK04844.1, ECO:0000313|Proteomes:UP000179642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 1 {ECO:0000313|EMBL:OIK04844.1,
RC ECO:0000313|Proteomes:UP000179642};
RA Lee L.-H., Ser H.-L., Law J.W.-F.;
RT "Genome sequence of Streptomyces sp. MUSC 1.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK04844.1}.
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DR EMBL; MLYO01000025; OIK04844.1; -; Genomic_DNA.
DR RefSeq; WP_071381497.1; NZ_MLYO01000025.1.
DR AlphaFoldDB; A0A1S2QFI2; -.
DR OrthoDB; 9816160at2; -.
DR Proteomes; UP000179642; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:OIK04844.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000179642}.
FT DOMAIN 16..270
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 327..684
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 693..754
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 755..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..784
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 488
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 361..362
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 592..593
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 784 AA; 85495 MW; F8AB56D95E454775 CRC64;
MITGRSYAVE PWAVRETALD LGVLAQSESV FALSNGHVGW RGNLDEGEPH GLPGSYLNGV
HEVHPLPYAE AGYGYPESGQ TVINVTNGKI LRLLVDDEPF DLRYGRLFAH ERVLDLRRGV
LERTCEWTSP AGSTVRVRST RLVSLTQRAV AAVAYEVEAV GCRSRVVIQS ELVAGETLPA
SDGDPRAAMA LQSPLEQEDH FAADRRLRLV HRTKRSGLRV AVAADHVVTG PERTTTRSES
GSDVARLTVT SVLEPGQTLR VEKLVAHGWS GTRSLPAMAD QVDAALAAAA QDGWQGLLAD
QRACLDDFWA GADVEVEGDE EIQQAVRFAL FHVLQAGARA EQRAIPAKGL TGSGYDGHAF
WDTEMFVLPV LTHTAPAAVA EALRWRYNTL DEARERAAQL GLAGAAFPWR TIAGPEGSAY
WPAGTAAFHV NAGIADAVVR YVEATGDDGF EREAGAELLV ETARLWRSLG HHDTRGGFHI
DGVTGPDEYS AVADDNTYTN LMARRNLLAA ADAVERHPDQ AARLGVDAEE SAAWRDAAEA
MHVPYNAELG VHEQHTGFTR YQRWDFAGTR PDQYPLLLHF PYFDLYRKQV VKQADLVLAM
YTCGDWFDGE GDEEQIARNF AYYEPLTVRD SSLSACCQAV MAAQTGHLDL AYAYTAEAAL
MDLQDLEHNT RDGLHIASLA DTWMALVAGF GGLRPDGENP RFAPRLPERL SRLAFHVRFR
GRTLRVDIGP DKATYALLAG PPLTLRHHGE PLTVTTADPA VRAVPPPVRR PAPEQPPHRA
PGAG
//
