ID A0A1S2RFH1_9BACI Unreviewed; 1045 AA.
AC A0A1S2RFH1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=BIV60_05240 {ECO:0000313|EMBL:OIK16417.1};
OS Bacillus sp. MUM 116.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1678002 {ECO:0000313|EMBL:OIK16417.1, ECO:0000313|Proteomes:UP000180019};
RN [1] {ECO:0000313|EMBL:OIK16417.1, ECO:0000313|Proteomes:UP000180019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUM 116 {ECO:0000313|EMBL:OIK16417.1,
RC ECO:0000313|Proteomes:UP000180019};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Bacillus sp. MUM 116.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK16417.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MLYR01000018; OIK16417.1; -; Genomic_DNA.
DR RefSeq; WP_071354665.1; NZ_MLYR01000018.1.
DR AlphaFoldDB; A0A1S2RFH1; -.
DR STRING; 1678002.BIV60_05240; -.
DR OrthoDB; 9782006at2; -.
DR Proteomes; UP000180019; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000180019};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 973..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..366
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 771..1037
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT COILED 77..104
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1045 AA; 113628 MW; A7E3296303E1B43F CRC64;
MKFIIKSKWI IMIAWIAIIV GLFMIAPNMA ELVRDKGQVD VPKGYSSHLA SEIMNQVQKQ
KDGGKETQVA LVFHDHKKLT KDEIEEAKKA IQALENNKEK LGITDIVSHF NEKSLKNQLV
AKDGKSILAS IKVAWNDREP KEVSAALYKT IKDIKVDHYY TSNWMINEDL MKSSQEGLKK
TEGITVVFIL AVLLLVFRSI VSPLIPLITV GITYLASQSI VAILVDKVNF PVSNYTQIFL
VCVLFGIGTD YCILLLSRFK EELSQRETMV DAIVQTYRTA GRTVFFSGLA VMVGFATIGF
SQFKLYQSSS AVAIGVAMLL IALFTIVPFF MAVLGRKLFW PSKGSAEHAE SKFWGAVGKF
SLARPFISLL IVAAICVPFL VTYDGKLSFN SLEEINGNVP SIRAFNAIAD SFGPGESMPT
QIVIKNDEAM NTTDYMELAE KISQEVEKVD RVDTVRSVTR PAGEKIKDFY VNKQAESLGE
GLGKGKDGIT KISGGLQEAG SKLSKSGPQL KGAVSGINGL ISGTNQLQTG LTDIQSNLAK
IENGIRQGSA GSTELKKGLE KTKAGAENLL AGYRKLQNGY QDIDANLKTL NAKYKDVANG
LTALSGALAQ IKGEDFAYLE SHYDGLAKEG QYQKIKGTVQ ALQQQLAPLS EGLNQLNAGL
SQITKGMDTA NTGFAKANGG QHDLAAGLEK LINGIEQQQA GLDKLANGQG QIIANMPKLT
NGISGINDGQ KQLLSGFGGL TGQLTQLSNG LDQSAKGLNQ VSDGLNSAQG YLSDLSDSTS
MSGFHMPKEV VKSKDFKQAL DTYLSDDWKV MTMDVVFKAN PYSNEAIHQV PEIKDAVKRA
VKNSKLENAV VAVGGITSSN ADLNKMSNQD FSRTVVLMLI GITLILILLF RSLIMPLYII
GSLILTYYTA MAMNEALFVN LLGYTGISWA VPFFGFVILM ALGVDYSIFL MDRFNEYKDL
KVADAMLLSM KKMGTVIISA AIILGGTFAA MMPSGMLSLL QIASIVLVGL LLYAFVILPL
FIPVMVKNFG KANWWPFNGM TNNLK
//
